T cells

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection.

Featured

Latest Research and Reviews

  • Research |

    Luster and colleagues show that Treg cells that reside in lung mucosa can respond to IL-33 upon allergen exposure and suppress innate cell responses. IL-33-activated ST2+ Treg cells secrete IL-35, which suppresses IL-17 production by γδ T cells and lessens eosinophil recruitment into the lung.

    • Lucas D. Faustino
    • , Jason W. Griffith
    • , Rod A. Rahimi
    • , Keshav Nepal
    • , Daniel L. Hamilos
    • , Josalyn L. Cho
    • , Benjamin D. Medoff
    • , James J. Moon
    • , Dario A. A. Vignali
    •  & Andrew D. Luster
  • Research |

    After activation, conventional T cells undergo metabolic reprogramming. de Kivit et al. show that in human thymic regulatory T cells, TNFR2 stimulation promotes a glycolytic switch with a preferential glucose-derived carbon flux into the TCA cycle to support suppressive functions.

    • Sander de Kivit
    • , Mark Mensink
    • , Anna T. Hoekstra
    • , Ilana Berlin
    • , Rico J. E. Derks
    • , Demi Both
    • , Muhammad A. Aslam
    • , Derk Amsen
    • , Celia R. Berkers
    •  & Jannie Borst
  • Reviews |

    Immune activating antibodies that target co-stimulatory molecules have altered the cancer therapy landscape. Here, Walker and colleagues discuss therapies — particularly those that target molecules in the same families as CTLA4 and PD1 or TNF receptor — that inhibit the immune system and are being investigated for the treatment of autoimmune diseases. They describe the future opportunities and challenges for the field, including combination approaches.

    • Natalie M. Edner
    • , Gianluca Carlesso
    • , James S. Rush
    •  & Lucy S. K. Walker
  • Reviews |

    A transcription factor network triggered by Notch signalling in the thymus guides proliferating, multipotent progenitor cells into the T cell pathway. This Review describes how these factors work to establish regulatory target specificity, epigenomic impact and irreversibility for T cell identity.

    • Hiroyuki Hosokawa
    •  & Ellen V. Rothenberg
  • Research
    | Open Access

    Intestinal IL-22 has important regulatory effects on the barrier and intestinal diseases and its production is controlled by the intestinal microbiome. Here the authors show that intestinal immune cell production of IL-22 is regulated by short chain fatty acids via an aryl hydrocarbon receptor and HIF1α-mediated mechanism that protects mice from intestinal inflammation.

    • Wenjing Yang
    • , Tianming Yu
    • , Xiangsheng Huang
    • , Anthony J. Bilotta
    • , Leiqi Xu
    • , Yao Lu
    • , Jiaren Sun
    • , Fan Pan
    • , Jia Zhou
    • , Wenbo Zhang
    • , Suxia Yao
    • , Craig L. Maynard
    • , Nagendra Singh
    • , Sara M. Dann
    • , Zhanju Liu
    •  & Yingzi Cong

News and Comment

  • News and Views |

    Two studies reveal a role for the transcriptional regulator BATF3 as a T cell–intrinsic factor mediating effective memory responses. This finding opens future avenues of investigation and opportunities to enhance cellular immunotherapy.

    • Caleb A. Lareau
    •  & Ansuman T. Satpathy
  • News and Views |

    Cytokines are well-known mediators of the immune response, but, recently, pleiotropic roles in the central nervous system have started to be uncovered. It is now shown that IL-17 directly modulates fear behavior in mice.

    • Rejane Rua
    •  & Nathalie Pujol
  • Research Highlights |

    A population of meningeal γδ T cells regulates anxiety-like behaviour and threat avoidance in mice through IL-17a production, which signals to neurons in the medial prefrontal cortex.

    • Kirsty Minton
  • News and Views |

    Comprehensive mapping reveals that functional CD4+ and CD8+ T cells targeting multiple regions of SARS-CoV-2 are maintained in the resolution phase of both mild and severe COVID-19, and their magnitude correlates with the antibody response.

    • Leo Swadling
    •  & Mala K. Maini
  • News and Views |

    Costimulatory blockade via the CTLA-4–Ig fusion protein abatacept is beneficial in patients with early-onset type 1 diabetes, but some individuals benefit more than others. A new study reports that the pretreatment abundance of T follicular helper (TFH) cells could predict clinical responses to abatacept.

    • Estelle Bettelli
    •  & Daniel J. Campbell
    Nature Immunology 21, 1141-1142