T cells

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection.

Latest Research and Reviews

  • Research |

    In a phase II clinical trial of patients with classical Hodgkin lymphoma, peripheral CD4+ T cell receptor diversity and the abundance of mature natural killer cells and CD3CD68+CD4+GrB+ innate cells were associated with favorable responses to anti-PD-1 monotherapy.

    • Fathima Zumla Cader
    • , Xihao Hu
    • , Walter L. Goh
    • , Kirsty Wienand
    • , Jing Ouyang
    • , Elisa Mandato
    • , Robert Redd
    • , Lee N. Lawton
    • , Pei-Hsuan Chen
    • , Jason L. Weirather
    • , Ron C. J. Schackmann
    • , Bo Li
    • , Wenjiang Ma
    • , Philippe Armand
    • , Scott J. Rodig
    • , Donna Neuberg
    • , X. Shirley Liu
    •  & Margaret A. Shipp
  • Research |

    Transient glucose restriction after the activation of CD8+ TE cells ex vivo induces metabolic remodelling that enhances effector functions and tumour clearance in mice.

    • Ramon I. Klein Geltink
    • , Joy Edwards-Hicks
    • , Petya Apostolova
    • , David O’Sullivan
    • , David E. Sanin
    • , Annette E. Patterson
    • , Daniel J. Puleston
    • , Nina A. M. Ligthart
    • , Joerg M. Buescher
    • , Katarzyna M. Grzes
    • , Agnieszka M. Kabat
    • , Michal Stanczak
    • , Jonathan D. Curtis
    • , Fabian Hässler
    • , Franziska M. Uhl
    • , Mario Fabri
    • , Robert Zeiser
    • , Edward J. Pearce
    •  & Erika L. Pearce
  • Research |

    The CTLA-4–Ig fusion protein (abatacept) can have beneficial effects in autoimmune disease. Walker and colleagues show in mouse and human type 1 diabetes that abatacept targets pathogenic follicular helper T cells, and the frequencies of these cells at baseline can be used to stratify treatment responses in patients.

    • Natalie M. Edner
    • , Frank Heuts
    • , Niclas Thomas
    • , Chun Jing Wang
    • , Lina Petersone
    • , Rupert Kenefeck
    • , Alexandros Kogimtzis
    • , Vitalijs Ovcinnikovs
    • , Ellen M. Ross
    • , Elisavet Ntavli
    • , Yassin Elfaki
    • , Martin Eichmann
    • , Roman Baptista
    • , Philip Ambery
    • , Lutz Jermutus
    • , Mark Peakman
    • , Miranda Rosenthal
    •  & Lucy S. K. Walker
  • Reviews |

    In this Progress article, Zeyu Chen and E. John Wherry summarize early reports of the T cell responses observed in patients with COVID-19, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.

    • Zeyu Chen
    •  & E. John Wherry
  • Research
    | Open Access

    Butyrophilin-like genes are emerging as central to tissue associated γδ T cell compartments. Here, the authors show that the butyropilin-like gene-products exert their effects as combinatorially diverse heteromers that differentially affect the selection and maintenance of skin-resident and gut-resident intraepithelial γδ T-cell populations.

    • Anett Jandke
    • , Daisy Melandri
    • , Leticia Monin
    • , Dmitry S. Ushakov
    • , Adam G. Laing
    • , Pierre Vantourout
    • , Philip East
    • , Takeshi Nitta
    • , Tomoya Narita
    • , Hiroshi Takayanagi
    • , Regina Feederle
    •  & Adrian Hayday

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