Synthetic organisms articles from across Nature Portfolio

Influenza virus is attenuated for vaccine production using PROTAC degradation technology.

Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal patterning.

Advances in synthetic biology allow the generation of ever more sophisticated engineered bacteria. In this Review, Riglar and Silver showcase recent highlights in engineered bacterial therapeutics and diagnostics and discuss how best to develop them for clinical application.

DNA-programmed assembly of cells (DPAC) allows the reconstitution of organoid-like structures with controlled size, shape, cell-type composition and spatial heterogeneity.