Synthetic organisms

Synthetic organisms are organisms for which a substantial portion of the genome or the entire genome has been designed or engineered.

Latest Research and Reviews

  • Research |

    Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal patterning.

    • Susanne C. van den Brink
    • , Anna Alemany
    • , Vincent van Batenburg
    • , Naomi Moris
    • , Marloes Blotenburg
    • , Judith Vivié
    • , Peter Baillie-Johnson
    • , Jennifer Nichols
    • , Katharina F. Sonnen
    • , Alfonso Martinez Arias
    •  & Alexander van Oudenaarden
    Nature 582, 405-409
  • Research |

    DNA-programmed assembly of cells (DPAC) allows the reconstitution of organoid-like structures with controlled size, shape, cell-type composition and spatial heterogeneity.

    • Michael E Todhunter
    • , Noel Y Jee
    • , Alex J Hughes
    • , Maxwell C Coyle
    • , Alec Cerchiari
    • , Justin Farlow
    • , James C Garbe
    • , Mark A LaBarge
    • , Tejal A Desai
    •  & Zev J Gartner
    Nature Methods 12, 975-981

News and Comment

  • Research Highlights |

    Two studies report synthetic genetic circuits for inducible asymmetric cell division that give rise to cellular differentiation in Escherichia coli.

    • Ashley York
  • Comments and Opinion |

    Synthetic biology is maturing into a true engineering discipline for model microorganisms, but remains far from straightforward for most eukaryotes. Here, we outline the key challenges facing those trying to engineer biology across eukaryota and suggest areas of focus that will aid future progress.

    • Francesca Ceroni
    •  & Tom Ellis