Stress and resilience

Definition

Stress and resilience refers to the individual's ability to withstand and adapt to ongoing stressors and adverse events.

Latest Research and Reviews

  • Reviews |

    In this Review, Kivimäki and Steptoe assess the current evidence on the association between stress and cardiovascular disease, covering the multiple roles of stress in the development and triggering of disease and as a determinant of prognosis and outcome. In addition, they discuss the clinical and public health importance of major stressors and the implications for prevention and treatment of cardiovascular disease.

    • Mika Kivimäki
    •  & Andrew Steptoe
  • Research | | open

    Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake.

    • Georgia Balsevich
    • , Alexander S. Häusl
    • , Carola W. Meyer
    • , Stoyo Karamihalev
    • , Xixi Feng
    • , Max L. Pöhlmann
    • , Carine Dournes
    • , Andres Uribe-Marino
    • , Sara Santarelli
    • , Christiana Labermaier
    • , Kathrin Hafner
    • , Tianqi Mao
    • , Michaela Breitsamer
    • , Marily Theodoropoulou
    • , Christian Namendorf
    • , Manfred Uhr
    • , Marcelo Paez-Pereda
    • , Gerhard Winter
    • , Felix Hausch
    • , Alon Chen
    • , Matthias H. Tschöp
    • , Theo Rein
    • , Nils C. Gassen
    •  & Mathias V. Schmidt
  • Research |

    Chronic social defeat stress induces loss of protein claudin-5, leading to abnormalities in blood vessel morphology, increased blood brain barrier permeability, infiltration of immune signals and depression-like behaviors.

    • Caroline Menard
    • , Madeline L. Pfau
    • , Georgia E. Hodes
    • , Veronika Kana
    • , Victoria X. Wang
    • , Sylvain Bouchard
    • , Aki Takahashi
    • , Meghan E. Flanigan
    • , Hossein Aleyasin
    • , Katherine B. LeClair
    • , William G. Janssen
    • , Benoit Labonté
    • , Eric M. Parise
    • , Zachary S. Lorsch
    • , Sam A. Golden
    • , Mitra Heshmati
    • , Carol Tamminga
    • , Gustavo Turecki
    • , Matthew Campbell
    • , Zahi A. Fayad
    • , Cheuk Ying Tang
    • , Miriam Merad
    •  & Scott J. Russo
    Nature Neuroscience 20, 1752–1760

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