Steroid hormones articles from across Nature Portfolio

Comparisons of steroid hormone concentrations in dentin samples from fossil mammoth tusks with those from a modern elephant tusk provide evidence of periodic increases in testosterone in the male mammoth characteristic of musth episodes.

PELP1 is a large scaffolding protein implicated in many cellular activities, including ribosome assembly as part of the Rix1 complex, comprising PELP1, WDR18, TEX10 and other components. Here, authors present the cryo-EM structure of PELP1 in complex with its binding partner WDR18, revealing the architecture of PELP1's numerous signaling motifs.

This Review discusses the ATP-binding cassette (ABC) proteins ABCB1 and ABCC1 and their preferential cellular export of cortisol and corticosterone, respectively. The article also explores the potential to select therapeutic glucocorticoids on the basis of their different tendencies for export to avoid harmful adverse effects.