Squamous cell carcinoma

Squamous cell carcinomas are neoplasms of the squamous cells that compose most of the skins upper layers (epidermis). They also occur in a range of tissues that include the mouth, oesophagus, urinary bladder, prostate, lung, vagina and cervix.

Latest Research and Reviews

Research
14 June 2022 | Open Access

Identification of metastatic primary cutaneous squamous cell carcinoma utilizing artificial intelligence analysis of whole slide images
- Jaakko S. Knuutila
- , Pilvi Riihilä
- & Veli-Matti Kähäri
Scientific Reports 12, 9876
Research
24 May 2022 | Open Access

The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces
- Yuji Kumagai
- , Junko Nio-Kobayashi
- & Hisashi Haga
Oncogenesis 11, 27
Research
09 May 2022 | Open Access

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
- L. Francisco Lorenzo-Martín
- , Mauricio Menacho-Márquez
- & Xosé R. Bustelo
Oncogene 41, 3341-3354
Reviews | 18 April 2022

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva
- Carlos Parra-Herran
- , Marisa R. Nucci
- & Jaclyn C. Watkins
Modern Pathology, 1-10
Research
07 April 2022 | Open Access

Spontaneous regression rates of actinic keratosis: a systematic review and pooled analysis of randomized controlled trials
- Theresa Steeb
- , Anne Petzold
- & Markus V. Heppt
Scientific Reports 12, 5884
Reviews
23 March 2022 | Open Access

Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma
- Glenn Geidel
- , Isabel Heidrich
- & Christoffer Gebhardt
npj Precision Oncology 6, 17

All Research & Reviews

News and Comment

Correspondence | 07 August 2021

Limitations of multivariate survival analysis
- Maximiliano Ramia de Cap
- & Sumedh Kaul
Modern Pathology 35, 993
Research Highlights | 01 July 2020

Integrating serine with tumour initiation

Baksh et al. have delineated a pathway through which serine availability is integrated with stem cell fate decisions and can control the initiation of epidermal squamous cell carcinomas.
- Sarah Seton-Rogers
Nature Reviews Cancer 20, 416
Research Highlights | 19 November 2019

Benevolent viruses in skin cancer

Strickley, Messerschmidt et al. show that beta human papilloma virus (β-HPV) infection itself is not causal in cutaneous squamous cell carcinoma (SCC) development in the context of immunosuppression — instead, the loss of β-HPV-mediated T cell immunity promotes SCC.
- Ulrike Harjes
Nature Reviews Cancer 20, 2
Research Highlights | 07 January 2019

Get to know your epigenetic target

Two studies suggest that caution is warranted in attempts to inhibit the histone methyltransferase G9a for cancer therapy, as its loss can promote tumour development and evolution.
- Sarah Seton-Rogers
Nature Reviews Cancer 19, 62-63
Research Highlights | 28 November 2018

Complementing tumour macrophage reprogramming
- M. Teresa Villanueva
Nature Reviews Drug Discovery 17, 862
Research Highlights | 19 June 2018

Cemiplimab effective in cutaneous SCC
- Peter Sidaway
Nature Reviews Clinical Oncology 15, 472

All News & Comment

Squamous cell carcinoma

Latest Research and Reviews

Identification of metastatic primary cutaneous squamous cell carcinoma utilizing artificial intelligence analysis of whole slide images

The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva

Spontaneous regression rates of actinic keratosis: a systematic review and pooled analysis of randomized controlled trials

Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma

News and Comment

Limitations of multivariate survival analysis

Integrating serine with tumour initiation

Benevolent viruses in skin cancer

Get to know your epigenetic target

Complementing tumour macrophage reprogramming

Cemiplimab effective in cutaneous SCC

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