Slow-wave sleep

Slow-wave sleep (SWS) refers to phase 3 sleep, which is the deepest phase of non-rapid eye movement (NREM) sleep, and is characterized by delta waves (measured by EEG). Dreaming and sleepwalking can occur during SWS. SWS is thought to be important for memory consolidation.

Latest Research and Reviews

  • Research
    | Open Access

    How are memories transferred from short-term to long-term storage? Here, the authors show that during deep (NREM) sleep, the prefrontal cortex initiates rapid, bidirectional interactions to trigger information transfer from the hippocampus to the neocortex.

    • Randolph F. Helfrich
    • , Janna D. Lendner
    • , Bryce A. Mander
    • , Heriberto Guillen
    • , Michelle Paff
    • , Lilit Mnatsakanyan
    • , Sumeet Vadera
    • , Matthew P. Walker
    • , Jack J. Lin
    •  & Robert T. Knight
  • Research |

    Fluorescence-based polysomnography in zebrafish reveals two major sleep signatures that share features with those of amniotes, which suggests that common neural sleep signatures emerged in the vertebrate brain over 450 million years ago.

    • Louis C. Leung
    • , Gordon X. Wang
    • , Romain Madelaine
    • , Gemini Skariah
    • , Koichi Kawakami
    • , Karl Deisseroth
    • , Alexander E. Urban
    •  & Philippe Mourrain
    Nature 571, 198-204
  • Reviews |

    Non-rapid eye movement (NREM) sleep parasomnias are thought to derive from incomplete arousal from NREM sleep. Here, the authors present evidence for coexistence of sleep-like and wake-like brain activity in disorders of arousal, including confusional arousals, sleep terrors and sleepwalking.

    • Anna Castelnovo
    • , Régis Lopez
    • , Paola Proserpio
    • , Lino Nobili
    •  & Yves Dauvilliers
  • Research |

    A subset of synaptic proteins are cumulatively phosphorylated during wakefulness and dephosphorylated during sleep, in accordance with sleep need; this may represent a common mechanism underlying regulation of both synaptic homeostasis and sleep–wake homeostasis.

    • Zhiqiang Wang
    • , Jing Ma
    • , Chika Miyoshi
    • , Yuxin Li
    • , Makito Sato
    • , Yukino Ogawa
    • , Tingting Lou
    • , Chengyuan Ma
    • , Xue Gao
    • , Chiyu Lee
    • , Tomoyuki Fujiyama
    • , Xiaojie Yang
    • , Shuang Zhou
    • , Noriko Hotta-Hirashima
    • , Daniela Klewe-Nebenius
    • , Aya Ikkyu
    • , Miyo Kakizaki
    • , Satomi Kanno
    • , Liqin Cao
    • , Satoru Takahashi
    • , Junmin Peng
    • , Yonghao Yu
    • , Hiromasa Funato
    • , Masashi Yanagisawa
    •  & Qinghua Liu
    Nature 558, 435-439

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