Featured
-
-
Article
| Open AccessIdentification of the Beer Component Hordenine as Food-Derived Dopamine D2 Receptor Agonist by Virtual Screening a 3D Compound Database
- Thomas Sommer
- , Harald Hübner
- & Timothy Clark
-
Article
| Open AccessNovel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue
- Z. Orfi
- , F. Waczek
- & A. Ullrich
-
Article
| Open AccessProtein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding
- Renjie Huang
- , Arnaud Bonnichon
- & Ivanhoe K. H. Leung
-
Article
| Open AccessUnusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne
- Li-Li Hong
- , Hao-Bing Yu
- & Hou-Wen Lin
-
Article
| Open AccessAntifouling potential of Nature-inspired sulfated compounds
- Joana R. Almeida
- , Marta Correia-da-Silva
- & Isabel Cunha
-
Article
| Open AccessA novel ECG analog 4-(S)-(2,4,6-trimethylthiobenzyl)-epigallocatechin gallate selectively induces apoptosis of B16-F10 melanoma via activation of autophagy and ROS
- Jing Xie
- , Ju-ping Yun
- & Zhuo-wei Hu
-
Article
| Open AccessDiscovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
- Kenjiro Hanaoka
- , Kiyoshi Sasakura
- & Tetsuo Nagano
-
Article
| Open AccessAntimicrobial mechanism of theaflavins: They target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway
- Xian Hui
- , Qiao Yue
- & Wen-Yun Gao
-
Article
| Open AccessInhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model
- Deepthi Yedlapudi
- , Gnanada S. Joshi
- & Aloke K. Dutta
-
Article
| Open AccessBumble bee parasite strains vary in resistance to phytochemicals
- Evan C. Palmer-Young
- , Ben M. Sadd
- & Lynn S. Adler
-
Article
| Open AccessIdentification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay
- Karine Normandin
- , Jean-François Lavallée
- & Vincent Archambault
-
Article
| Open AccessRhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle
- Yong Li
- , Yun-Bao Liu
- & Shi-Shan Yu
-
Article
| Open AccessA fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
- Alan M. Jones
- , Isaac M. Westwood
- & Rob L. M. van Montfort
-
Article
| Open AccessModification of plant cell wall structure accompanied by enhancement of saccharification efficiency using a chemical, lasalocid sodium
- Emiko Okubo-Kurihara
- , Misato Ohtani
- & Minami Matsui
-
Article
| Open AccessIdentification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries
- Tomomi Imamura
- , Kyota Fujita
- & Hitoshi Okazawa
-
Article
| Open AccessA simple and cost-saving phenotypic drug susceptibility testing of HIV-1
- Yunceng Weng
- , Ling Zhang
- & Chengyao Li
-
Article
| Open AccessHSCCC-based strategy for preparative separation of in vivo metabolites after administration of an herbal medicine: Saussurea laniceps, a case study
- Tao Yi
- , Lin Zhu
- & Hu-Biao Chen
-
Article
| Open AccessComparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ
- Yasumitsu Kondoh
- , Kaori Honda
- & Hiroyuki Osada
-
Article
| Open AccessA Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors
- Laura Goracci
- , Nathalie Deschamps
- & Alessandra Nurisso
-
Article
| Open AccessFunction-specific virtual screening for GPCR ligands using a combined scoring method
- Albert J. Kooistra
- , Henry F. Vischer
- & Chris de Graaf
-
Article
| Open AccessNew Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity
- Tao Zhang
- , Jin-Guang Si
- & Zhong-Mei Zou
-
Article
| Open AccessDiscovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae
- Ulrike Grienke
- , Martina Richter
- & Judith M. Rollinger
-
Article
| Open AccessCell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
- Ji heon Rhim
- , Xiangjian Luo
- & Xiaofeng Xia
-
Article
| Open AccessProteome-wide drug screening using mass spectrometric imaging of bead-arrays
- Ying Zhou
- , Ziying Liu
- & Mark J. Lim
-
Article
| Open AccessUltra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs
- Alba Espargaró
- , Aina Medina
- & Raimon Sabate
-
Article
| Open AccessSmall Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction
- Michaele B. Manigrasso
- , Jinhong Pan
- & Ann Marie Schmidt
-
Article
| Open AccessEvaluation of the antinociceptive activities of enaminone compounds on the formalin and hot plate tests in mice
- Willias Masocha
- , Samuel B. Kombian
- & Ivan O. Edafiogho
-
Article
| Open AccessCharacterization of the aodA, dnmA, mnSOD and pimA genes in Aspergillus nidulans
- Éva Leiter
- , Hee-Soo Park
- & István Pócsi
-
Article
| Open AccessGFP-complementation assay to detect functional CPP and protein delivery into living cells
- Nadia Milech
- , Brooke AC Longville
- & Richard M Hopkins
-
Article
| Open AccessTargeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily
- Valentina Gandin
- , Alessandro Ferrarese
- & Giovanni Marzaro
-
Article
| Open AccessDiscovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus
- Koichiro Nakano
- , Takeru Chigira
- & Kouhei Tsumoto
-
Article
| Open AccessDiscovery of a selective, safe and novel anti-malarial compound with activity against chloroquine resistant strain of Plasmodium falciparum
- Ankita Agarwal
- , Sarvesh Paliwal
- & Sarika Gunjan
-
Article
| Open AccessCoumarin derivatives from Ainsliaea fragrans and their anticoagulant activity
- Liang Lei
- , Yong-bo Xue
- & Yong-hui Zhang
-
Article
| Open AccessDiscovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT
- Xia Wang
- , Tian-Ying Xu
- & Chao-Yu Miao
-
Article
| Open AccessChemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats
- Maryam Hajrezaie
- , Keivan Shams
- & Mahmood Ameen Abdulla
-
Article
| Open AccessSynthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways
- Maryam Zahedifard
- , Fadhil Lafta Faraj
- & Mahmood Ameen Abdulla
-
Article
| Open AccessDiscovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay
- Chenzeng Liao
- , Yanlin Wang
- & Sen Liu
-
Article
| Open AccessApoptotic effect of novel Schiff Based CdCl2(C14H21N3O2) complex is mediated via activation of the mitochondrial pathway in colon cancer cells
- Maryam Hajrezaie
- , Mohammadjavad Paydar
- & Mahmood Ameen Abdulla
-
Article
| Open AccessAnthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock
- Karothu Durga Prasad
- , Jamma Trinath
- & Tayur N. Guru Row
-
Article
| Open AccessQuantitative High-Throughput Profiling of Environmental Chemicals and Drugs that Modulate Farnesoid X Receptor
- Chia-Wen Hsu
- , Jinghua Zhao
- & Menghang Xia
-
Article
| Open AccessProtective Effect of Aframomum melegueta phenolics Against CCl4-Induced Rat Hepatocytes Damage; Role of Apoptosis and Pro-inflammatory Cytokines inhibition
- Ali M. El-Halawany
- , Riham Salah El Dine
- & Masao Hattori
-
Article
| Open AccessHis-tag protein monitoring by a fast mix-and-measure immunoassay
- Thomas Kreisig
- , Agneta A. Prasse
- & Thole Zuchner
-
Article
| Open AccessQuantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
- Bhagwan Yadav
- , Tea Pemovska
- & Tero Aittokallio
-
Article
| Open Access2′-Epi-uscharin from the Latex of Calotropis gigantea with HIF-1 Inhibitory Activity
- Supawadee Parhira
- , Guo-Yuan Zhu
- & Zhi-Hong Jiang