Rhesus macaque

The rhesus macaque (Macaca mulatta) is an Asian Old World monkey used in biomedical research due to its closeness to humans and to the ease of rearing the animal in captivity.

Latest Research and Reviews

Research
05 November 2020 | Open Access

Placenta-derived macaque trophoblast stem cells: differentiation to syncytiotrophoblasts and extravillous trophoblasts reveals phenotypic reprogramming
- Jenna Kropp Schmidt
- , Logan T. Keding
- & Thaddeus G. Golos
Scientific Reports 10, 19159
Research
21 August 2019 | Open Access

Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques

High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cells and a local type-I interferon response.
- Shaheed A. Abdulhaqq
- , Melween Martinez
- & Luis J. Montaner
Nature Communications 10, 3753
Research
17 July 2019 | Open Access

A macaque connectome for large-scale network simulations in TheVirtualBrain
- Kelly Shen
- , Gleb Bezgin
- & Anthony R. McIntosh
Scientific Data 6, 123
Research
17 December 2018 | Open Access

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche

Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque seminiferous tubules, which matures these into late PGCs and spermatogonia-like cells.
- Enrique Sosa
- , Di Chen
- & Amander T. Clark
Nature Communications 9, 5339
Research | 02 July 2018

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Zika virus infection during pregnancy is associated with an increased rate of fetal loss in nonhuman primates, as reported in this multicenter analysis.
- Dawn M. Dudley
- , Koen K. Van Rompay
- & David H. O’Connor
Nature Medicine 24, 1104-1107
Research | 26 July 2017

Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques
- K D Kauffman
- , M A Sallin
- & D L Barber
Mucosal Immunology 11, 462-473