Regenerative medicine articles within Nature Materials

Featured

• News & Views | 02 February 2023

  A bioadhesive robot to activate muscles

  Soft actuators composed of a tough bioadhesive/elastomer shell encapsulating a stimuli-responsive metallic spring provide in situ mechanical stimulation of skeletal muscles to promote muscle tissue rehabilitation and prevent atrophy.

  • Xuanhe Zhao

• Article | 09 November 2020

  Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

  Microporous annealed-particle degradable scaffolds have been developed and shown to induce type 2 innate and adaptive immune response that facilitated skin wound healing.

  • Donald R. Griffin
  • , Maani M. Archang
  •  & Philip O. Scumpia

• News & Views | 21 May 2019

  A pulpy story

  Over-expression of a transcriptional factor, Alx3, has been shown to revitalize the regenerative capacity of adult progenitor cells to promote enhanced stromal vascularization and formation of parenchymal dental pulp tissue in vivo.

  • Sarah E. Millar

• Article | 21 May 2018

  Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke

  Stimulation of angiogenesis after stroke is not always an effective therapy. An injectable hydrogel with pro-angiogenic and immune-modulating factors is now shown to support blood vessel, axonal and functional recovery following stroke.

  • Lina R. Nih
  • , Shiva Gojgini
  •  & Tatiana Segura

• Article | 02 October 2017

  Mechanical confinement regulates cartilage matrix formation by chondrocytes

  The mechanical properties of biomaterials affect cell growth through mechanotransduction signals. Here, hydrogels with fast stress relaxation were developed and showed increased cartilage matrix formation by cartilage cells compared to slow relaxation hydrogels.

  • Hong-pyo Lee
  • , Luo Gu
  •  & Ovijit Chaudhuri

• News & Views | 01 September 2017

  Sticking around vessels

  A study demonstrates that controlled integrin binding on a biomaterial was capable of promoting vascular cell sprouting and formation of a non-leaky blood vessel network in a healthy and diseased state.

  • Michael R. Blatchley
  •  & Sharon Gerecht

• Article | 07 August 2017

  Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability

  Ligand–integrin binding is essential for cell and tissue growth. Here, controlled integrin binding on a hyaluronic acid hydrogel was shown to promote endothelial cell sprouting in vitro and vessel network formation in vivo.

  • Shuoran Li
  • , Lina R. Nih
  •  & Tatiana Segura

• News & Views | 20 February 2013

  Keeping track

  Assessing when cell death occurs following in vivo transplantation of stem cells is challenging. Now, pH-sensitive hydrogel capsules containing arginine-based liposomes are shown to act as magnetic resonance imaging contrast agents, allowing cell death to be monitored within the capsules.

  • Keren Ziv
  •  & Sanjiv S. Gambhir

• News & Views | 01 July 2010

  Noodle gels for cells

  Heating and cooling of peptide amphiphile suspensions converts disorganized nanofibres into liquid-crystalline nanofibre bundles that gel on addition of salts. The noodle-shaped strings of gel can entrap and align cells.

  • Timothy J. Deming