Physiology articles within Nature Reviews Cardiology

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  • Review Article |

    Aging is accompanied by changes in vascular structure and function leading to arterial stiffness, which is an important predictor of cardiovascular disease. Hemodynamic changes associated with arterial aging include increased pulse pressure, pulse wave velocity, and wave reflection. In this Review, Michel Safar describes the features of arterial aging, and how blockade of the renin–angiotensin–aldosterone system may ameliorate the effects of this process.

    • Michel E. Safar

  • Review Article |

    Echocardiography is commonly used to assess hypertrophic myopathies. The authors of this Review outline imaging modalities that are more sensitive than standard echocardiography, which can be used to determine characteristic changes in regional deformation at an earlier stage, and provide more information about the underlying processes associated with different hypertrophic myopathies.

    • Maja Cikes
    • , George R. Sutherland
    •  & Bart H. Bijnens

  • News & Views |

    Two large trials were conducted to evaluate the effects of an angiotensin-converting-enzyme inhibitor, an angiotensin-receptor blocker or a combination of both in high cardiovascular risk patients. A decrease in the prevalence of left ventricular hypertrophy (LVH) was reported, but this did not translate into a prognostic benefit. New-onset LVH was associated with an increase in cardiovascular events.

    • Alberto Zanchetti

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