Personalized medicine articles from across Nature Portfolio

Personalized medicine is a therapeutic approach involving the use of an individual’s genetic and epigenetic information to tailor drug therapy or preventive care.

Latest Research and Reviews

Reviews | 11 May 2023

Prioritization of genes associated with type 2 diabetes mellitus for functional studies

More genetic variants associated with type 2 diabetes mellitus are being identified. This Perspective article outlines various tools and platforms that can be applied to prioritize candidate genes associated with an increased risk of disease for functional validation.
- Wei Xuan Tan
- , Xueling Sim
- & Adrian K. K. Teo
Nature Reviews Endocrinology, 1-10
Research
08 May 2023 | Open Access

Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder
- Alex G. Segura
- , Elena de la Serna
- & Josefina Castro-Fornieles
Translational Psychiatry 13, 155
Research | 27 April 2023

Polygenic risk scores analyses of psychiatric and metabolic traits with antipsychotic-induced weight gain in schizophrenia: an exploratory study
- Kazunari Yoshida
- , Victoria S. Marshe
- & Daniel J. Müller
The Pharmacogenomics Journal, 1-8
Reviews
19 April 2023 | Open Access

Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings
- Emily M. Hicks
- , Carina Seah
- & Laura M. Huckins
Translational Psychiatry 13, 129
Research
10 April 2023 | Open Access

Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project
- Hai Le
- , Konstantina Dimitrakopoulou
- & Harriet Cullen
Translational Psychiatry 13, 121
Research | 13 March 2023

Multiancestry genomic and transcriptomic analysis of gastric cancer

A cross-ancestry genomic and transcriptomic cohort of gastric cancer highlights significantly mutated genes and mutational signatures, some of which are ancestry-specific.
- Yasushi Totoki
- , Mihoko Saito-Adachi
- & Tatsuhiro Shibata
Nature Genetics 55, 581-594

All Research & Reviews

News and Comment

Comments & Opinion | 18 May 2023

Including multiracial individuals is crucial for race, ethnicity and ancestry frameworks in genetics and genomics

Current ontologies of race, ethnicity and genetic ancestry rely on categorization, but have limitations — as exemplified by multiracial individuals. We argue that including these individuals will foster inclusion by better capturing complex identities, with equity benefits for the full human population.
- Daphne O. Martschenko
- , Hannah Wand
- & Genevieve L. Wojcik
Nature Genetics, 1-6
Research Highlights | 27 April 2023

A call to personalize anti-hypertensive treatments

The PHYSIC trial reveals substantial variability in how people respond to four different classes of blood-pressure-lowering drugs — highlighting the need to personalize treatments.
- Karen O’Leary
Nature Medicine
Editorial | 25 April 2023

The gene-therapy revolution risks stalling if we don’t talk about drug pricing

Regulation and new intellectual property laws are needed to reduce the cost of gene-editing treatments and fulfil their promise to improve human health.

Nature 616, 629-630
Correspondence | 25 April 2023

Annotating and prioritizing human non-coding variants with RegulomeDB v.2
- Shengcheng Dong
- , Nanxiang Zhao
- & Benjamin C. Hitz
Nature Genetics 55, 724-726
Research Highlights | 13 April 2023

Rare disease gene mining
- Kyle Vogan
Nature Genetics 55, 524
Research Highlights | 24 March 2023

Pharmacogenomics in the clinic
- Monica Wang
Nature Reviews Nephrology 19, 277

All News & Comment

Personalized medicine articles from across Nature Portfolio

Latest Research and Reviews

Prioritization of genes associated with type 2 diabetes mellitus for functional studies

Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder

Polygenic risk scores analyses of psychiatric and metabolic traits with antipsychotic-induced weight gain in schizophrenia: an exploratory study

Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings

Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project

Multiancestry genomic and transcriptomic analysis of gastric cancer

News and Comment

Including multiracial individuals is crucial for race, ethnicity and ancestry frameworks in genetics and genomics

A call to personalize anti-hypertensive treatments

The gene-therapy revolution risks stalling if we don’t talk about drug pricing

Annotating and prioritizing human non-coding variants with RegulomeDB v.2

Rare disease gene mining

Pharmacogenomics in the clinic

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