Neurodegeneration articles from across Nature Portfolio

Daly, Danson and colleagues employ a multi-omic approach in neuroglioma cells to characterise endolysosomal dysfunction caused by perturbation of the evolutionarily conserved Retromer complex, highlighting Retromer’s neuroprotective function.

Mice with the P361R mutation in the lysosomal ceramidase, Asah1, exhibit a spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME)-like phenotype and may be a valuable tool to evaluate future therapies for SMA-PME.

The membrane-shaping protein ARL6IP1 is involved in the selective degradation of the endoplasmic reticulum, and this process depends on its ubiquitination and interaction with other membrane-shaping proteins such as FAM134B.

This Perspective describes the clinical relevance of animal models in dementia for translational research. The authors emphasize incorporating aging as a component in model organisms to understand its contribution to disease pathogenesis.

Pan, Huang, Cai et al. develop computational models to predict brain β-amyloid (Aβ) pathology from plasma biomarkers, cognitive test scores and key demographics. The models accurately predict brain Aβ positivity enabling assessment of Aβ pathology in a non-invasive and cost-effective way.