Featured
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Editorial
| Open AccessGuest Edited Collection: Gravitational biology and space medicine
A return to the Moon, Mars expeditions, and a rise in space tourism will lead to an increasing number of human spaceflights. The ‘Gravitational biology and space medicine’ Collection focuses on the challenges to the health of humans in space during long-term space missions and the physiological changes during short-term altered gravity conditions, the possible influence of space radiation, available countermeasures and possible applications on Earth. In addition, studies reporting on in vivo changes in space-flown mice were published. Finally, this Collection also brings together articles reporting experiments using cells cultured under conditions of real microgravity on the International Space Station, or exposed in ground-based facilities, in order to study morphological and molecular alterations in different cell types.
- Daniela Grimm
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Article
| Open AccessA Modified Collagen Dressing Induces Transition of Inflammatory to Reparative Phenotype of Wound Macrophages
- Amitava Das
- , Motaz Abas
- & Chandan K. Sen
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Article
| Open AccessAssociation between genetic polymorphisms of NRF2, KEAP1, MAFF, MAFK and anti-tuberculosis drug-induced liver injury: a nested case-control study
- Shixian Chen
- , Hongqiu Pan
- & Shaowen Tang
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Article
| Open AccessDistinct spectrum of microRNA expression in forensically relevant body fluids and probabilistic discriminant approach
- Shuntaro Fujimoto
- , Sho Manabe
- & Keiji Tamaki
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Article
| Open AccessVU0155069 inhibits inflammasome activation independent of phospholipase D1 activity
- Sung Kyun Lee
- , Ye Seon Kim
- & Yoe-Sik Bae
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Article
| Open AccessThe role of extracellular matrix in mouse and human corneal neovascularization
- M. Barbariga
- , F. Vallone
- & G. Ferrari
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Article
| Open AccessComparisons of lung and gluteus transcriptome profiles between yaks at different ages
- Jin-Wei Xin
- , Zhi-Xin Chai
- & Jin-Cheng Zhong
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Article
| Open AccessHigh-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent
- Dorothea M. Heuberger
- , Shefali Harankhedkar
- & Johanna Buschmann
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Article
| Open AccessHLA class I-restricted T cell epitopes isolated and identified from myeloid leukemia cells
- Lydon Wainaina Nyambura
- , Alejandro Azorin Muñoz
- & Peter Walden
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Article
| Open AccessEvaluation of a Recombinant Newcastle Disease Virus Expressing Human IL12 against Human Breast Cancer
- Zahiah Mohamed Amin
- , Muhamad Alhapis Che Ani
- & Khatijah Yusoff
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Article
| Open AccessDual-probe molecular MRI for the in vivo characterization of atherosclerosis in a mouse model: Simultaneous assessment of plaque inflammation and extracellular-matrix remodeling
- Carolin Reimann
- , Julia Brangsch
- & Marcus R. Makowski
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Article
| Open AccessAssociation between single nucleotide polymorphisms within HLA region and disease relapse for patients with hematopoietic stem cell transplantation
- Ding-Ping Chen
- , Su-Wei Chang
- & Ching-Ping Tseng
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Article
| Open AccessClinical Features of Neuroblastoma with 11q Deletion: An Increase in Relapse Probabilities in Localized and 4S Stages
- Antonio Juan Ribelles
- , Sandra Barberá
- & Victoria Castel
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Article
| Open AccessMice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
- Kathrine Sivertsen Åsrud
- , Line Pedersen
- & Marit Bakke
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Article
| Open AccessTargeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes
- Mariusz G. Fleszar
- , Jerzy Wiśniewski
- & Małgorzata Krzystek-Korpacka
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Article
| Open AccessGlucagon-like peptide-2 rescues memory impairments and neuropathological changes in a mouse model of dementia induced by the intracerebroventricular administration of streptozotocin
- Sachie Sasaki-Hamada
- , Masaatsu Ikeda
- & Jun-Ichiro Oka
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Article
| Open AccessPreparation of β-CD-DPPE-Dox Nanomedicine and Its’ Application as the Anticancer and Antitumor Drug
- Miaomiao Yan
- , Anran Cai
- & Guangcheng Wei
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Article
| Open AccessMicroarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations
- Hongling Wang
- , Frank Stahl
- & Carsten Zeilinger
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Article
| Open AccessTargeted multiplex proteomics for molecular prescreening and biomarker discovery in metastatic colorectal cancer
- Garazi Serna
- , Fiorella Ruiz-Pace
- & Paolo Nuciforo
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Article
| Open AccessHorizontal and vertical integrative analysis methods for mental disorders omics data
- Shuaichao Wang
- , Xingjie Shi
- & Shuangge Ma
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Article
| Open AccessControlling Obesity and Metabolic Diseases by Hydrodynamic Delivery of a Fusion Gene of Exendin-4 and α1 Antitrypsin
- Mingming Gao
- & Dexi Liu
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Article
| Open AccessBerberine inhibits adipocyte differentiation, proliferation and adiposity through down-regulating galectin-3
- Can Wang
- , Yan Wang
- & Jian-Dong Jiang
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Article
| Open AccessA common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins
- Jane Alrø Bøtkjær
- , Pernille Rimmer Noer
- & Claus Yding Andersen
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Article
| Open AccessA small gene sequencing panel realises a high diagnostic rate in patients with congenital nystagmus following basic phenotyping
- Luke O’Gorman
- , Chelsea S. Norman
- & Jay E. Self
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Article
| Open AccessProteomic Investigations of Autism Brain Identify Known and Novel Pathogenetic Processes
- Joseph R. Abraham
- , Nicholas Szoko
- & Marvin R. Natowicz
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Article
| Open AccessA genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
- Hyong Woo Choi
- , Lei Wang
- & Daniel F. Klessig
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Article
| Open AccessNovel Human Anti-PD-L1 mAbs Inhibit Immune-Independent Tumor Cell Growth and PD-L1 Associated Intracellular Signalling
- Margherita Passariello
- , Anna Morena D’Alise
- & Claudia De Lorenzo
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Article
| Open AccessReduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides
- May T. Aung-Htut
- , Iain Comerford
- & Steve D. Wilton
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Article
| Open AccessCigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients
- Giulia Pintarelli
- , Sara Noci
- & Francesca Colombo
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Article
| Open AccessCompton imaging with 99mTc for human imaging
- Makoto Sakai
- , Yoshiki Kubota
- & Takashi Nakano
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Article
| Open AccessHepatitis C virus (HCV) genotype 1b displays higher genetic variability of hypervariable region 1 (HVR1) than genotype 3
- Maciej Janiak
- , Karol Perlejewski
- & Kamila Caraballo Cortés
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Article
| Open AccessExtracellular vesicle-coupled miRNA profiles in follicular fluid of cows with divergent post-calving metabolic status
- Tsige Hailay
- , Michael Hoelker
- & Dawit Tesfaye
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Article
| Open Accessl-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
- Johanna Huttunen
- , Soile Peltokangas
- & Kristiina M. Huttunen
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Article
| Open AccessIdentification of stably expressed housekeeping miRNAs in endothelial cells and macrophages in an inflammatory setting
- Fabian Link
- , Knut Krohn
- & Julia Schumann
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Article
| Open AccessAntimicrobial action of autologous platelet-rich plasma on MRSA-infected skin wounds in dogs
- Haithem A. Farghali
- , Naglaa A. AbdElKader
- & Mahmoud Elhariri
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Article
| Open AccessCochlear Glucocorticoid Receptor and Serum Corticosterone Expression in a Rodent Model of Noise-induced Hearing Loss: Comparison of Timing of Dexamethasone Administration
- Seung-Hun Lee
- , Ah-Ra Lyu
- & Yong-Ho Park
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Article
| Open Accessde novo MEPCE nonsense variant associated with a neurodevelopmental disorder causes disintegration of 7SK snRNP and enhanced RNA polymerase II activation
- Pauline E. Schneeberger
- , Tatjana Bierhals
- & Kerstin Kutsche
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Article
| Open AccessDNA methylation silencing of microRNA gene methylator in the precancerous background mucosa with and without gastric cancer: Analysis of the effects of H. pylori eradication and long-term aspirin use
- Jiro Watari
- , Chiyomi Ito
- & Hiroto Miwa
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Article
| Open AccessExpression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines
- Petar Ozretić
- , Nikolina Hanžić
- & Neda Slade
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Article
| Open AccessAlbumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin
- Mustafa Nazıroğlu
- , Bilal Çiğ
- & László Pecze
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Article
| Open AccessEvaluation of the role of STAP1 in Familial Hypercholesterolemia
- Magdalena Danyel
- , Claus-Eric Ott
- & Ilja Demuth
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Article
| Open AccessMechanism of Interleukin-4 Reducing Lipid Deposit by Regulating Hormone-Sensitive Lipase
- Ming-Yuh Shiau
- , Pei-Hua Chuang
- & Yih-Hsin Chang
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Article
| Open AccessX chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients
- Clara Xiol
- , Silvia Vidal
- & Cristina Villar
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Article
| Open AccessMorphological and Molecular Changes in Juvenile Normal Human Fibroblasts Exposed to Simulated Microgravity
- Christoph Buken
- , Jayashree Sahana
- & Daniela Grimm
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Article
| Open AccessPseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction
- Nicholas M. Maurice
- , Brahmchetna Bedi
- & Ruxana T. Sadikot
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Article
| Open Access11PS04 is a new chemical entity identified by microRNA-based biosensing with promising therapeutic potential against cancer stem cells
- Tania Aguado
- , José A. Romero-Revilla
- & José-María Sánchez-Puelles
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Article
| Open AccessIntrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α
- Liangzhong Zhao
- , Ziyu Liu
- & Guiying Li
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Article
| Open AccessMRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models
- Sara Werner
- , Jana Lützkendorf
- & Guido Posern
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Article
| Open AccessAllelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia
- Aarif M. N. Batcha
- , Stefanos A. Bamopoulos
- & Tobias Herold