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| Open AccessMechanism of high affinity inhibition of the human urate transporter URAT1
- Philip K. Tan
- , Traci M. Ostertag
- & Jeffrey N. Miner
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| Open AccessA new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites
- Natalia V. Barykina
- , Oksana M. Subach
- & Grigori N. Enikolopov
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| Open AccessA general and efficient strategy for generating the stable enzymes
- Xiao-Fei Zhang
- , Guang-Yu Yang
- & Yan Feng
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| Open AccessHumanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma
- Yi-Fan Zhang
- & Mitchell Ho
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| Open AccessA highly efficient sorbitol dehydrogenase from Gluconobacter oxydans G624 and improvement of its stability through immobilization
- Tae-Su Kim
- , Sanjay K. S. Patel
- & Jung-Kul Lee
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| Open AccessSTAR: a simple TAL effector assembly reaction using isothermal assembly
- Sabine Gogolok
- , Claudia Garcia-Diaz
- & Steven M. Pollard
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| Open AccessEnhanced pinocembrin production in Escherichia coli by regulating cinnamic acid metabolism
- Weijia Cao
- , Weichao Ma
- & Pingkai Ouyang
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| Open AccessTheophylline controllable RNAi-based genetic switches regulate expression of lncRNA TINCR and malignant phenotypes in bladder cancer cells
- Zhicong Chen
- , Yuchen Liu
- & Zhiming Cai
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| Open AccessDual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy
- Marie Godar
- , Virginia Morello
- & Christophe Blanchetot
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Article
| Open AccessCRISPR-PCS: a powerful new approach to inducing multiple chromosome splitting in Saccharomyces cerevisiae
- Yu Sasano
- , Koki Nagasawa
- & Satoshi Harashima
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| Open AccessControl of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody
- Anil Tiwari
- , Rajendra Kumar
- & Manni Luthra-Guptasarma
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| Open AccessExploring the induction of preproinsulin-specific Foxp3+ CD4+ Treg cells that inhibit CD8+ T cell-mediated autoimmune diabetes by DNA vaccination
- Katja Stifter
- , Cornelia Schuster
- & Reinhold Schirmbeck
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Article
| Open AccessEngineering de novo disulfide bond in bacterial α-type carbonic anhydrase for thermostable carbon sequestration
- Byung Hoon Jo
- , Tae Yoon Park
- & Hyung Joon Cha
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Article
| Open AccessFunctional map of arrestin binding to phosphorylated opsin, with and without agonist
- Christian Peterhans
- , Ciara C. M. Lally
- & Jörg Standfuss
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| Open AccessIntramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains
- Ana Alvarez-Cienfuegos
- , Natalia Nuñez-Prado
- & Luis Alvarez-Vallina
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Article
| Open AccessIdentification and Characterisation of a pH-stable GFP
- Tania Michelle Roberts
- , Fabian Rudolf
- & Martin Held
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Article
| Open AccessImproved catalytic efficiency, thermophilicity, anti-salt and detergent tolerance of keratinase KerSMD by partially truncation of PPC domain
- Zhen Fang
- , Juan Zhang
- & Jian Chen
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Article
| Open AccessCRISPR/Cas9-Mediated Immunity to Geminiviruses: Differential Interference and Evasion
- Zahir Ali
- , Shakila Ali
- & Magdy M. Mahfouz
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| Open AccessTerminator Operon Reporter: combining a transcription termination switch with reporter technology for improved gene synthesis and synthetic biology applications
- Massimiliano Zampini
- , Luis A. J. Mur
- & Alison Kingston-Smith
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| Open AccessTargeting membrane proteins for antibody discovery using phage display
- Martina L. Jones
- , Mohamed A. Alfaleh
- & Stephen M. Mahler
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| Open AccessAn intein-mediated modulation of protein stability system and its application to study human cytomegalovirus essential gene function
- Deng Pan
- , Baoqin Xuan
- & Zhikang Qian
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Article
| Open AccessMechanistic and quantitative insight into cell surface targeted molecular imaging agent design
- Liang Zhang
- , Sumit Bhatnagar
- & Greg M. Thurber
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Article
| Open AccessIn vitro template-change PCR to create single crossover libraries: a case study with B. thuringiensis Cry2A toxins
- Changlong Shu
- , Jianqiao Zhou
- & Jie Zhang
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| Open AccessRobust Type-specific Hemisynapses Induced by Artificial Dendrites
- Eun Joong Kim
- , Chang Su Jeon
- & Taek Dong Chung
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| Open AccessA Recombinant Secondary Antibody Mimic as a Target-specific Signal Amplifier and an Antibody Immobilizer in Immunoassays
- Junseon Min
- , Eun Kyung Song
- & Sebyung Kang
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| Open AccessEngineering formation of multiple recombinant Eut protein nanocompartments in E. coli
- Mark Held
- , Alexander Kolb
- & Claudia Schmidt-Dannert
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| Open AccessPado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions
- Bok Eum Kang
- & Bradley J. Baker
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| Open AccessAn alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design
- Yongping Zhao
- , Congsheng Zhang
- & Chuanxiao Xie
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| Open AccessRetargeting the Clostridium botulinum C2 toxin to the neuronal cytosol
- Benjamin J. Pavlik
- , Elizabeth J. Hruska
- & Paul H. Blum
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| Open AccessIngestion of genetically modified yeast symbiont reduces fitness of an insect pest via RNA interference
- Katherine A. Murphy
- , Christine A. Tabuloc
- & Joanna C. Chiu
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| Open AccessAnti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages
- Philippe Abdel-Sayed
- , Ariane Kaeppeli
- & Lee Ann Applegate
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| Open AccessDirected evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts
- Marco Schütz
- , Jendrik Schöppe
- & Andreas Plückthun
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| Open AccessHigh-resolution Identification and Separation of Living Cell Types by Multiple microRNA-responsive Synthetic mRNAs
- Kei Endo
- , Karin Hayashi
- & Hirohide Saito
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Article
| Open AccessDiscovery of 12-mer peptides that bind to wood lignin
- Asako Yamaguchi
- , Katsuhiro Isozaki
- & Takashi Watanabe
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| Open AccessEffects of three permeases on arginine utilization in Saccharomyces cerevisiae
- Peng Zhang
- , Guocheng Du
- & Jingwen Zhou
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| Open AccessSpyRing interrogation: analyzing how enzyme resilience can be achieved with phytase and distinct cyclization chemistries
- Christopher Schoene
- , S. Paul Bennett
- & Mark Howarth
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| Open Access2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation
- Elise Cachat
- , Weijia Liu
- & Jamie A. Davies
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| Open AccessA universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity
- Xueping Chen
- , Dandan Zhou
- & Guoming Xie
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| Open AccessDigital detection of endonuclease mediated gene disruption in the HIV provirus
- Ruth Hall Sedlak
- , Shu Liang
- & Keith R. Jerome
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Article
| Open AccessMolecular evolution of gas cavity in [NiFeSe] hydrogenases resurrected in silico
- Takashi Tamura
- , Naoki Tsunekawa
- & Fumitoshi Sato
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| Open AccessPlug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization
- Karl D. Brune
- , Darren B. Leneghan
- & Mark Howarth
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| Open AccessEvolved hexose transporter enhances xylose uptake and glucose/xylose co-utilization in Saccharomyces cerevisiae
- Amanda Reider Apel
- , Mario Ouellet
- & Aindrila Mukhopadhyay
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| Open AccessFunctional properties of flagellin as a stimulator of innate immunity
- Yuan Lu
- & James R. Swartz
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| Open AccessDesign of chimeric antigen receptors with integrated controllable transient functions
- Alexandre Juillerat
- , Alan Marechal
- & Philippe Duchateau
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| Open AccessRational design of ultrastable and reversibly photoswitchable fluorescent proteins for super-resolution imaging of the bacterial periplasm
- Mariam El Khatib
- , Alexandre Martins
- & Virgile Adam
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| Open AccessAllosteric effects of chromophore interaction with dimeric near-infrared fluorescent proteins engineered from bacterial phytochromes
- Olesya V. Stepanenko
- , Mikhail Baloban
- & Vladislav V. Verkhusha
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| Open AccessArchitecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications
- Ken-ichiro Matsunaga
- , Michiko Kimoto
- & Ichiro Hirao
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| Open AccessCharacterization of marine diatom-infecting virus promoters in the model diatom Phaeodactylum tricornutum
- Takashi Kadono
- , Arisa Miyagawa-Yamaguchi
- & Masao Adachi
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| Open AccessMinimal domain of bacterial phytochrome required for chromophore binding and fluorescence
- Konstantin A. Rumyantsev
- , Daria M. Shcherbakova
- & Vladislav V. Verkhusha