Microtubules are cylindrical polymers composed of alpha and beta tubulin. They are a major component of the cytoskeleton and mediate crucial cellular functions including formation of the mitotic spindle that segregates chromosomes during cell division and intracellular trafficking.

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News and Comment

  • News & Views |

    Primary cilia transduce cues, including Hedgehog (Hh) signals, and possess doublet microtubules that interact with kinesin motors. The kinesin KIF7 is important for Hh signalling and binds to GLI transcription factors. Haque et al. reveal that, surprisingly, GLI proteins bind a DNA-like part of KIF7 to promote their accumulation at the ciliary tip.

    • Dhivya Kumar
    •  & Jeremy F. Reiter
    Nature Cell Biology 24, 1015-1016
  • News & Views |

    Integrin-mediated substrate-rigidity sensing triggers microtubule acetylation, modulating mechanosensitive cellular responses and focal adhesion dynamics, subsequently promoting actomyosin organization and collective cell migration.

    • Kseniia Porshneva
    •  & Guillaume Montagnac
    Nature Materials 21, 271-272
  • Research Highlights |

    Torrino et al. show that the stiffness of the extracellular matrix regulates microtubule posttranslational modification via glutamylation, which impacts microtubule dynamics and cell invasiveness.

    • Paulina Strzyz