News & Views |
Featured
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Comment |
Cell biology through the macroscopic lens
Macroscale analogies are a powerful conceptual tool with which we can gain insight into the structures and processes of the microscopic world of cell biology.
- Michelle A. Baird
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Research Briefing |
Topological control of synthetic morphogenesis
Organs in the human body have complex networks of fluid-filled tubes and loops with different geometries and topologies. By studying self-organized, synthetic tissues, the link between topological transitions and the emergence of tissue architecture was revealed.
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Letter
| Open AccessTopological morphogenesis of neuroepithelial organoids
During development, tissues with complex topology emerge from collections of cells with simple geometry. This process in neuroepithelial organoids is governed by two topologically distinct modes of epithelial fusion.
- Keisuke Ishihara
- , Arghyadip Mukherjee
- & Frank Jülicher
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Letter |
Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation
Experiments on cell monolayers on corrugated hydrogels reveal the effects of local curvature on the shape of cells and nuclei. A vertex model lends support to the idea that the modulation of tissue thickness may enable curvature sensing.
- Marine Luciano
- , Shi-Lei Xue
- & Sylvain Gabriele
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Article |
Bioelectrical domain walls in homogeneous tissues
A detailed theoretical and experimental investigation of homogeneous cell tissues finds that they can undergo spontaneous spatial symmetry breaking through a purely electrophysiological mechanism.
- Harold M. McNamara
- , Rajath Salegame
- & Adam E. Cohen
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Article |
Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina
The structural integrity of a cell’s nucleus is maintained by a polymer network known as the nuclear lamina. A simple biophysical theory reveals two regimes by which this network can rupture, depending on the structure of the nuclear envelope.
- Dan Deviri
- , Charlotte R. Pfeifer
- & Samuel A. Safran
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Article |
Membrane-induced hydroelastic migration of a particle surfing its own wave
A rigid particle moving along a soft wall feels a repulsive force that can reduce its drag. Evidence now suggests that for thin enough walls the particle can be displaced appreciably—a finding that may have implications for biological membranes.
- Bhargav Rallabandi
- , Naomi Oppenheimer
- & Howard A. Stone
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Perspective |
In pursuit of the mechanics that shape cell surfaces
Robust and responsive, the surface of a cell is as important as its interior when it comes to mechanically regulating form and function. New techniques are shedding light on this role, and a common language to describe its properties is now needed.
- Alba Diz-Muñoz
- , Orion D. Weiner
- & Daniel A. Fletcher
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Article |
Membrane fluctuations mediate lateral interaction between cadherin bonds
The proteins that adhere cells together in tissue assemble in domains near the cell–cell interface. Experiments, simulations and theory show that formation of these domains is regulated by the membrane itself — with an explicit role for fluctuations.
- Susanne F. Fenz
- , Timo Bihr
- & Ana-Sunčana Smith
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Article |
Size-dependent protein segregation at membrane interfaces
Segregation between binding and non-binding proteins in the space between cells is critical for immune response. In vitro experiments show that size alone suffices to explain the exclusion of non-binding proteins from membrane interfaces.
- Eva M. Schmid
- , Matthew H. Bakalar
- & Daniel A. Fletcher
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Article |
Liposome adhesion generates traction stress
Biomembranes can transmit forces over cellular length scales. Now, however, their active role in generating stress is demonstrated. The adhesion and spreading of a liposome that has no active cytoskeletal machinery are shown to contract the substrate, exerting traction stresses that are comparable with those of living cells.
- Michael P. Murrell
- , Raphaël Voituriez
- & Margaret L. Gardel
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