This Review discusses the susceptibility of the fetal immune system to intrauterine growth restriction (IUGR) and the consequences on pancreatic islet development, which might influence the pathogenesis of type 2 diabetes mellitus in individuals affected by IUGR. The potential for immunomodulation as a therapeutic approach to treat IUGR-induced type 2 diabetes mellitus will also be discussed.
- Thea N. Golden
- Rebecca A. Simmons