Quality control of misfolded glycosylphosphatidylinositol-anchored proteins (GPI-APs) does not occur through ER-associated degradation, as the lipid anchor precludes retrotranslocation across the ER membrane. Instead, different organisms have developed distinct solutions to prevent the accumulation of misfolded GPI-APs.
- Leticia Lemus
- Ramanujan S. Hegde
- Veit Goder