Lineage tracking

Lineage tracking methods follow the position and behaviour of cells and their descendents over time. Cells are typically labelled and/or imaged in real time or at frequent time intervals to determine their lineage.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A new study in Cell describes the CRISPR array repair lineage tracing (CARLIN) engineered mouse line that genomically encodes all the components for CRISPR-based lineage tracking at single-cell resolution.

    • Darren J. Burgess
  • Research Highlights |

    Two new studies in Science combine single-cell RNA sequencing with either lineage tracing or a computational framework to link transcriptomes to future developmental trajectories.

    • Darren J. Burgess
  • News & Views |

    Early studies showing that KIT+ cardiac progenitor cells (CPCs) could differentiate into cardiomyocytes generated excitement regarding their potential therapeutic application. Subsequent studies called their functional relevance into question, and while claims for a contribution of KIT+ CPCs to myocardial regeneration continue, two new studies confirm the doubts about their relevance to cardiomyogenesis and provide unexpected new insights.

    • Giovanni Maroli
    •  & Thomas Braun
  • Research Highlights |

    Three new studies in Nature and Nature Biotechnology report methods for dissecting transcriptomic cell phenotypes and lineage history simultaneously by combining single-cell RNA sequencing (scRNA-seq) with CRISPR-based lineage tracing.

    • Darren J. Burgess
  • Research Highlights |

    Using DNA barcoding, Lanet al. investigated the clonal evolution and dynamics of glioblastoma cells, and propose a model whereby proliferative heterogeneity is derived from stochastic fate decisions made by a homogeneous population of glioblastoma stem cells and their progeny.

    • Conor A. Bradley
    Nature Reviews Cancer 17, 574-575