Leukocytes articles within Nature Reviews Cardiology

Featured

• Research Highlight | 13 November 2023

  Disrupting a cell-specific miRNA–CXCR4 interaction is atheroprotective in mice

  An approach that increases the expression of the chemokine receptor CXCR4 in vascular cells by targeting a microRNA-based repressive pathway attenuates atherosclerosis in mice and promotes atheroprotective functions in human and mouse vascular cells in vitro.

  • Irene Fernández-Ruiz

• Research Highlight | 30 November 2022

  α-Myosin-specific CD8⁺ T cells drive ICI-related myocarditis

  Cytotoxic CD8⁺ T cells specific for the cardiac protein α-myosin heavy chain have a key role in immune-checkpoint-inhibitor-associated myocarditis, according to a study published in Nature.

  • Irene Fernández-Ruiz

• Research Highlight | 11 May 2020

  T_reg cells promote plaque regression

  A new study shows that regulatory T cells have essential roles in atherosclerotic plaque regression by promoting the resolution of plaque inflammation through suppression of macrophage and T cell pro-inflammatory responses and induction of a pro-resolving macrophage phenotype.

  • Irene Fernández-Ruiz

• Review Article | 16 March 2020

  T cell subsets and functions in atherosclerosis

  Accumulating evidence supports the critical role of T cells as drivers and modifiers of atherosclerosis. In this Review, Ley and colleagues describe the latest advances in our understanding of the role of T cell subsets in atherosclerosis, discuss the process of T cell homing to atherosclerotic plaques and highlight potential T cell-related therapies for atherosclerosis.

  • Ryosuke Saigusa
  • , Holger Winkels
  •  & Klaus Ley

• Research Highlight | 29 March 2019

  Cholesterol efflux drives stem cell expansion in hypercholesterolaemia

  AIBP-mediated cholesterol efflux promotes the specification of haematopoietic stem and progenitor cells (HSPCs) in embryogenesis and induces adult HSPC expansion in hypercholesterolaemic conditions, mediated by SREBP2-regulated activation of Notch signalling.

  • Irene Fernández-Ruiz

• Research Highlight | 19 February 2019

  T cells in the gut promote CVD and slow metabolism

  A subset of T cells present in the small intestine modulate systemic metabolism and contribute to cardiovascular disease by limiting the bioavailability of the incretin hormone GLP1.

  • Irene Fernández-Ruiz

• Review Article | 04 September 2018

  The interstitium in cardiac repair: role of the immune–stromal cell interplay

  Research on cardiac repair and regeneration is shifting from a stem cell focus towards the dynamic interplay of stromal and immune cells of the cardiac interstitium. This Review provides new insights into the immunoregulatory functions of cardiac interstitial cells and their complex network of interactions, highlighting the therapeutic potential for cardiac disease.

  • Elvira Forte
  • , Milena Bastos Furtado
  •  & Nadia Rosenthal

• Research Highlight | 26 July 2018

  Unravelling the atheroprotective mechanisms of LDL immunization

  • Irene Fernández-Ruiz

• Research Highlight | 10 April 2018

  Redefining leukocytes in atherosclerosis

  • Irene Fernández-Ruiz

• Research Highlight | 15 June 2017

  Novel target with antithrombotic potential and low bleeding risk

  • Irene Fernández-Ruiz