Immunological memory articles from across Nature Portfolio

Immunological memory refers to the ability of the immune system to respond more rapidly and effectively to a pathogen that has been encountered previously.

Featured

News & Views | 29 May 2023

Immunity to COVID after vaccination in First Nations peoples is affected by comorbidities

Nature Immunology 24, 901-902

Latest Research and Reviews

Research
22 May 2023 | Open Access

Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide

Cytotoxic lymphocytes (CTL) are important in the control of HIV and some HLA alleles are associated with protection or susceptibility to disease. Here the authors characterise an epitope where variants bind to HLA-B57 or HLA-B53 and they characterise the structural and functional TCR recognition differences.
- Xiaolong Li
- , Nishant Kumar Singh
- & Jia-huai Wang
Nature Communications 14, 2929
Reviews | 08 May 2023

CD4⁺ T cell memory

In this Review, Künzli and Masopust provide updates on our understanding of the biology of memory CD4⁺ T cells as well as key technological advances that facilitate their characterization.
- Marco Künzli
- & David Masopust
Nature Immunology 24, 903-914
Research
27 April 2023 | Open Access

Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Boyman and colleagues perform phenotypic and B cell receptor sequencing analysis of memory B cell subsets in severe acute respiratory syndrome coronavirus 2-infected and subsequently vaccinated individuals up to 1 year post-infection to show that single memory B cell clones can adopt different trajectories.
- Yves Zurbuchen
- , Jan Michler
- & Onur Boyman
Nature Immunology 24, 955-965
Research
25 April 2023 | Open Access

Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice

A critical role of human CD4 cytotoxic T lymphocytes in mediating tumor clearance independent of CD8 T cells is reported in humanized immune system mice implanted with HT-29 colorectal tumors.
- Wen Lin
- , Varan Singh
- & Yi-Fen Lu
Communications Biology 6, 447
Research
24 April 2023 | Open Access

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Becher et al. perform a head-to-head comparison of multiple severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) vaccine prime-boost combinations and analyze the ensuing humoral and cellular responses in a large randomized cohort.
- Nicolás Gonzalo Nuñez
- , Jonas Schmid
- & Burkhard Becher
Nature Immunology 24, 941-954
Reviews
24 February 2023 | Open Access

Potential links between the microbiota and T cell immunity determine the tumor cell fate
- Amir Hossein Mohseni
- , Sedigheh Taghinezhad-S
- & Dan Li
Cell Death & Disease 14, 154

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News and Comment

News & Views | 29 May 2023

Immunity to COVID after vaccination in First Nations peoples is affected by comorbidities

First Nations peoples of Australia have disproportionate rates of chronic comorbidities such as diabetes and renal disease. A study of COVID vaccination in First Nations peoples reveals that perturbed antibody responses can occur in individuals with comorbidities in a way strongly associated with altered IgG glycosylation patterns.

Nature Immunology 24, 901-902
Research Highlights | 24 April 2023

Primary vaccination imprint
- Ioana Visan
Nature Immunology 24, 732
Research Highlights | 10 April 2023

Pyrimidine nucleotide starvation induces a decrease in the number of effector T cells but not memory T cells
- Gwanghun Kim
- , Hyun Mu Shin
- & Hang-Rae Kim
Cellular & Molecular Immunology, 1-2
News & Views | 05 April 2023

B cells and T follicular helper-like cells within lung granulomas are required for TB control

We show a crucial protective function for T follicular helper (T_FH)-like cells localized within granuloma-associated lymphoid tissue for Mycobacterium tuberculosis control in mouse models of tuberculosis. Antigen-specific B cells contribute to this strategic localization and the maturation of cytokine-producing T_FH-like cells.

Nature Immunology 24, 753-754
Research Highlights | 23 March 2023

Vaccine-induced memory
- Ioana Visan
Nature Immunology 24, 560
Research Highlights | 23 March 2023

Reservoirs of allergic memory

Two preprints by Koenig et al. and Ota et al. characterize a subset of memory B cells that can retain allergen-specific IgE memory.
- Michelle Tran
- & Cecilia Berin
Nature Reviews Immunology 23, 272

All News & Comment

Immunological memory articles from across Nature Portfolio

Featured

Immunity to COVID after vaccination in First Nations peoples is affected by comorbidities

Latest Research and Reviews

Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide

CD4⁺ T cell memory

Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Potential links between the microbiota and T cell immunity determine the tumor cell fate

News and Comment

Immunity to COVID after vaccination in First Nations peoples is affected by comorbidities

Primary vaccination imprint

Pyrimidine nucleotide starvation induces a decrease in the number of effector T cells but not memory T cells

B cells and T follicular helper-like cells within lung granulomas are required for TB control

Vaccine-induced memory

Reservoirs of allergic memory

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