Research Highlight |
Featured
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Review Article |
Diagnosis and management of lymphomas and other cancers in HIV-infected patients
Patients infected with HIV seem to develop certain types of cancer more frequently than uninfected people. Specifically, lymphomas represent the most frequent malignancy affecting patients with HIV. This Review focuses on the different type of lymphomas that generally occur in patients infected with HIV, as well as other cancers. The authors provide an update of epidemiological data and diagnostic issues, and discuss the most-appropriate strategies for the management of patients with both HIV and lymphomas.
- Antonino Carbone
- , Emanuela Vaccher
- & Silvia Franceschi
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Review Article |
T-cell therapy in the treatment of post-transplant lymphoproliferative disease
This Review describes current strategies and future approaches to improve T cell-based therapies to treat post-transplant lymphoproliferative disease, a serious and often life-threatening complication that is associated with Epstein-Barr virus and can occur after haematopoietic stem-cell or solid organ transplantation.
- Catherine M. Bollard
- , Cliona M. Rooney
- & Helen E. Heslop
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Review Article |
Castleman's disease—a two compartment model of HHV8 infection
Castleman's disease is an infectious disease of the lymph node that causes either local symptoms or a systemic inflammatory syndrome. This Review discusses the viral causes of the disease and the mechanisms of its subsequent progression. The efficacy of established treatment options for this disease and of potential novel therapies is outlined.
- Klaus-Martin Schulte
- & Nadia Talat
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Case Study |
T-cell lymphoproliferative disorder potentially induced by imatinib in a patient with GIST
A 71-year-old male patient was diagnosed with aKIT-positive gastrointestinal stromal tumor (GIST). The patient received adjuvant imatinib but developed several subcutaneous and intra-abdominal tumor lesions after 4 months of treatment. A T-cell lymphoproliferative disorder was suspected. The authors discuss the potential of imatinib to induce reversible clonal T-cell proliferations in patients with GIST who develop new tumor manifestations that are suspicious for relapse.
- Mareike Verbeek
- , Falko Fend
- & Justus Duyster
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News & Views |
ATG and Newton's third law of motion
Patients with hematological malignancies have a risk of developing graft-versus-host disease (GVHD) following allogeneic hematopoietic stem-cell transplantation. The addition of ATG to prophylaxis regimens decreases the incidence of GVHD without compromising overall survival in these patients.
- Claudio G. Brunstein
