Human papilloma virus

Human papilloma virus (HPV) is an infectious agent belonging to the virus family Papillomaviridae, members of which have tropism for cutaneous epithelium and mucosal epithelium. There are more than 120 different HPV types, with HPV-16 and HPV-18 having a strong association with cervical cancer.

Latest Research and Reviews

  • Research
    | Open Access

    An effective vaccine for human papillomavirus (HPV) needs to protect from several genotypes. Here, Wang et al. provide a strategy to produce single capsomere-hybrid virus-like particle (chVLP) composed of capsomers of different genotypes and show that a nona-type chVLP induces similar levels of neutralizing antibodies as an approved HPV vaccine.

    • Daning Wang
    • , Xinlin Liu
    • , Minxi Wei
    • , Ciying Qian
    • , Shuo Song
    • , Jie Chen
    • , Zhiping Wang
    • , Qin Xu
    • , Yurou Yang
    • , Maozhou He
    • , Xin Chi
    • , Shiwen Huang
    • , Tingting Li
    • , Zhibo Kong
    • , Qingbing Zheng
    • , Hai Yu
    • , Yingbin Wang
    • , Qinjian Zhao
    • , Jun Zhang
    • , Ningshao Xia
    • , Ying Gu
    •  & Shaowei Li
  • Research
    | Open Access

    The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesions or cervical cancer.

    • Bin Zhu
    • , Yanzi Xiao
    • , Meredith Yeager
    • , Gary Clifford
    • , Nicolas Wentzensen
    • , Michael Cullen
    • , Joseph F. Boland
    • , Sara Bass
    • , Mia K. Steinberg
    • , Tina Raine-Bennett
    • , DongHyuk Lee
    • , Robert D. Burk
    • , Maisa Pinheiro
    • , Lei Song
    • , Michael Dean
    • , Chase W. Nelson
    • , Laurie Burdett
    • , Kai Yu
    • , David Roberson
    • , Thomas Lorey
    • , Silvia Franceschi
    • , Philip E. Castle
    • , Joan Walker
    • , Rosemary Zuna
    • , Mark Schiffman
    •  & Lisa Mirabello
  • Research |

    A mouse model of papillomavirus infection reveals that skin colonization with commensal papillomaviruses protects the immunocompetent host against chemical- and UV-induced skin cancer through CD8+ T cell immunity.

    • John D. Strickley
    • , Jonathan L. Messerschmidt
    • , Mary E. Awad
    • , Tiancheng Li
    • , Tatsuya Hasegawa
    • , Dat Thinh Ha
    • , Henry W. Nabeta
    • , Paul A. Bevins
    • , Kenneth H. Ngo
    • , Maryam M. Asgari
    • , Rosalynn M. Nazarian
    • , Victor A. Neel
    • , Alfred Bennett Jenson
    • , Joongho Joh
    •  & Shadmehr Demehri
    Nature 575, 519-522
  • Research
    | Open Access

    The authors identify circular RNAs (circRNA) from human papillomavirus and show that circRNA-encoded E7 contributes to cancer cell growth in vitro and in tumor xenografts. Furthermore, circE7 is present in TCGA RNA-Seq data from HPV-positive cancers.

    • Jiawei Zhao
    • , Eunice E. Lee
    • , Jiwoong Kim
    • , Rong Yang
    • , Bahir Chamseddin
    • , Chunyang Ni
    • , Elona Gusho
    • , Yang Xie
    • , Cheng-Ming Chiang
    • , Michael Buszczak
    • , Xiaowei Zhan
    • , Laimonis Laimins
    •  & Richard C. Wang

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