In Brief |
Featured
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Brief Communication |
A microfluidic device for epigenomic profiling using 100 cells
ChIP-seq performed in a microfluidic device on chromatin isolated from as few as 100 cells allows the profiling of epigenetic histone marks.
- Zhenning Cao
- , Changya Chen
- & Chang Lu
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Article |
Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms
The combination of deep chromatin immunoprecipitation–sequencing with a statistical test that scores the correlation of peak height and allelic imbalance allows de novo discovery of histone acetylation quantitative trait loci without prior genotyping or genome sequencing.
- Ricardo Cruz-Herrera del Rosario
- , Jeremie Poschmann
- & Shyam Prabhakar
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Brief Communication |
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
Targeting a histone demethylase to specific enhancers with Cas9 allows modification of epigenetic marks at the enhancers.
- Nicola A Kearns
- , Hannah Pham
- & René Maehr
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Research Highlights |
Modifying chromatin to shut off enhancers
Transcription activator–like effectors (TALEs) fused to enzymes that change chromatin signatures interrogate the role of enhancers in gene expression.
- Nicole Rusk
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Technology Feature |
Mass spectrometry for chromatin biology
To discover new histone marks and interactions, researchers turn to the sophisticated instruments of proteomics.
- Monya Baker
