Genome

The genome is the full genetic complement of an organism, encoded in either DNA or, in many viruses, RNA. It includes both the genes and non-coding sequences.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A study in Nature Communications shows that horizontal transfer of bacterial chromosomes by phage-mediated lateral transduction renders them more mobile than many classically defined mobile genetic elements, including plasmids and transposons.

    • Dorothy Clyde
  • News & Views |

    Four new reports uncover the lineage relationships between cells throughout the body using mutations in the genome as cellular barcodes. The mutational composition of different tissues provides insights into both developmental processes and organ homeostasis, and may have important implications for our understanding of hereditary diseases such as polycystic kidney disease.

    • Parker C. Wilson
    •  & Benjamin D. Humphreys
  • Research Highlights |

    Tom Misteli highlights a 2006 study by Shopland et al., which used relatively simple methods to visualize characteristics of chromosome organization. Their conclusions foreshadowed key concepts in the field: topologically associating domains, compartments and cell-to-cell heterogeneity in genome organization.

    • Tom Misteli
  • Research Highlights |

    This molecular phenotyping study shows that common variants in mitochondrial DNA associated with diseases of ageing influence cellular protein homeostasis, and that this link is mediated by circulating levels of N-formylmethionine, the initiating amino acid in mitochondrial protein synthesis.

    • Caroline Barranco