Genetic engineering articles within Nature Genetics

Featured

  • Article |

    BEAN is a Bayesian approach for analyzing base editing screens with improved effect size quantification and variant classification. Applied to low-density lipoprotein (LDL)-associated common variants and saturation base editing of LDLR, BEAN identifies new LDL uptake genes and offers insights into variant structure–pathogenicity mechanisms.

    • Jayoung Ryu
    • , Sam Barkal
    •  & Luca Pinello

  • Article |

    A comparison of fetal hemoglobin gene editing strategies using human sickle cell disease donor cells and in vivo transplantation finds that adenine base editing of the –175A>G site in the γ-globin gene promoters results in durable and potent expression.

    • Thiyagaraj Mayuranathan
    • , Gregory A. Newby
    •  & Jonathan S. Yen

  • Article |

    Genome-wide CRISPR screening identifies thymidine nucleotide metabolism as a key regulator of human telomere length. Thymidine supplementation promotes telomere elongation in cells derived from patients with telomere biology disorders.

    • William Mannherz
    •  & Suneet Agarwal

  • Comment |

    Thirty years ago, I had the privilege of launching Nature Genetics, the first spin-off journal bearing the famous Nature logo. Spurred on by the Human Genome Project, there were high hopes for the new journal and indeed the future of human genetics. But there was little expectation that we would launch a science publishing franchise of more than 30 sister journals — or be able to therapeutically rewrite the faulty genomes of patients. Here, I reflect on the humble beginnings of Nature Genetics and 30 years of progress in genetics.

    • Kevin Davies

  • Perspective |

    Recent technologies allow experimental manipulation of chromatin conformation. This Perspective discusses the insights obtained from gain-of-function studies that engineer the three-dimensional genome.

    • Di Zhang
    • , Jessica Lam
    •  & Gerd A. Blobel

  • Comment |

    The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

    • Marie-Christine Birling
    • , Atsushi Yoshiki
    •  & Stephen A. Murray

  • News & Views |

    How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.

    • Erika C. Anderson
    •  & Elphège P. Nora

  • Article |

    Insertion of a tissue-invariant chromatin domain boundary into 16 ectopic loci leads to various structural phenotypes, which depend on local chromatin features, CTCF binding and transcriptional status.

    • Di Zhang
    • , Peng Huang
    •  & Gerd A. Blobel

  • Article |

    Analysis with alleles encoding pharmacologically degradable Mediator subunits shows that Mediator acts as a global coactivator that facilitates transcription globally but is acutely required for cell-type-specific gene regulatory circuits.

    • Martin G. Jaeger
    • , Björn Schwalb
    •  & Georg E. Winter

  • Editorial |

    The development of CRISPR–Cas technology and its applications in biomedical research have generated much excitement. If fully realized, this technology has the potential to help treat or prevent severe diseases. However, these tools also carry considerable risk if improperly used. The scientific community must promote constructive dialogue among its members and within society at large to ensure that research on genome editing is conducted responsibly.

  • Article |

    A coupled knockdown-editing screen shows that CRISPR–Cas9 editing in human cells requires the Fanconi anemia pathway, which acts by diverting double-strand break repair away from non-homologous end joining toward single-strand template repair.

    • Chris D. Richardson
    • , Katelynn R. Kazane
    •  & Jacob E. Corn

  • Editorial |

    The journal endorses the principle of transparency in the production of genome-edited crops and livestock as a precondition for the registration of a breed or cultivar, with no further need for regulation or distinction of these goods from the products of traditional breeding.

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