Gene expression articles from across Nature Portfolio

Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins, however non-protein coding genes can encode functional RNA, including ribosomal RNA (rRNA), transfer RNA (tRNA) or small nuclear RNA (snRNA).

Latest Research and Reviews

News and Comment

  • News |

    It’s a creative, perhaps wild and sometimes challenging encounter. But some labs make a habit of inviting artists in.

    • Vivien Marx
    Nature Methods 20, 319
  • News & Views |

    A meta-analysis of harmonized human brain RNA-seq datasets creates expression quantitative trait locus (eQTL) maps for multiple ancestries and brain regions, predicts cell-type-dependent eQTLs and produces gene networks. This prioritizes genes for multiple brain-related diseases, serving as a promising step toward the identification of central nervous system (CNS) drug targets.

    Nature Genetics 55, 363-364
  • Research Highlights |

    A paper in Science reports that circadian gene expression in humans is affected by sex and age, findings that might explain differential disease prevalence among these groups and have implications for treatment.

    • Dorothy Clyde
  • News & Views |

    Using cap analysis of gene expression, we have constructed a map of the genome regulatory network (promoters and enhancers) in healthy and failing human hearts. Analysis of this map demonstrates differential transcriptional regulation in cardiac chambers, disease states, and ischemic and non-ischemic cardiomyopathies. This information could lead to tailored therapies.

  • News & Views |

    Bivalent genes are regulated by a balance between repressive Polycomb group proteins and activating trithorax group proteins. A new study has revealed that MENIN, an accessory component of KMT2A/B methyltransferase complexes, has an unorthodox role in repressing bivalent genes, alongside Polycomb repressive complexes.

    • Xue Qing David Wang
    •  & Yali Dou
    Nature Cell Biology 25, 209-210