Gene delivery articles within Nature Materials

Featured

• News & Views | 15 December 2011

  Charged for success

  DNA-complexated cationic polymers with reduced charge density, high molecular weight and increased hydrophobicity show a lack of detectable cytotoxicity and efficiently deliver the apoptosis-inducing TRAIL gene to transplanted tumours in mice.

  • Enrico Mastrobattista
  •  & Wim E. Hennink

• Article | 04 December 2011

  Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery

  Many synthetic polymer nanoparticles used for non-viral gene delivery contain excess cations on their surface, which makes the particles cytotoxic and the delivery of genes inefficient. Terpolymers with a low charge density, high molecular weight and increased hydrophobicity are now shown to have minimal toxicity, and to efficiently deliver the apoptosis-inducing TRAIL gene to transplanted tumours in mice.

  • Jiangbing Zhou
  • , Jie Liu
  •  & W. Mark Saltzman