Gastroenterology articles from across Nature Portfolio

Gastrointestinal research in Latin America is hampered by a lack of financial support and by biases, affecting research advancement in the region and career development of Latin American scientists. Engagement of the next generation of leaders and established scientists is, therefore, essential to avoid perpetuation of the existing inequalities.

A careful integration of the effectiveness and safety of the therapies for inflammatory bowel disease, considering patients’ disease risks, treatment complications and preferences, is warranted to inform the positioning of therapies in clinical practice. Precision medicine might help choose the best option for an individual patient.

Key studies published in 2022 highlight the emergence of several novel drugs for inflammatory bowel disease. Head-to-head trials and network meta-analyses have also been conducted to identify the sequencing of these treatments, but we still have a long way to go to achieve personalized medicine.