Functional dyspepsia articles from across Nature Portfolio

Functional dyspepsia is impaired digestion for which there is no evidence of an organic disease that could explain the symptoms. Abdominal pain, bloating and quickly feeling full when eating are some of the symptoms of functional dyspepsia.

Latest Research and Reviews

Research
23 June 2022 | Open Access

Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case–control study on prepubertal Chinese boys
- Oscar W. H. Wong
- , Angela M. W. Lam
- & Patrick W. L. Leung
Scientific Reports 12, 10659
Research
15 October 2020 | Open Access

Duodenal acidification induces gastric relaxation and alters epithelial barrier function by a mast cell independent mechanism
- Hanne Vanheel
- , Maria Vicario
- & Tim Vanuytsel
Scientific Reports 10, 17448
Research
12 February 2020 | Open Access

Prevalence of Non-Celiac Gluten Sensitivity in Patients with Refractory Functional Dyspepsia: a Randomized Double-blind Placebo Controlled Trial
- Bijan Shahbazkhani
- , Mohammad M. Fanaeian
- & Mohammad Rostami-Nejad
Scientific Reports 10, 2401
Research
24 July 2019 | Open Access

Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia
- Junying Wei
- , Qiong Man
- & Luqi Huang
Scientific Reports 9, 10713
Research
29 March 2018 | Open Access

Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation
- Hanne Vanheel
- , Maria Vicario
- & Ricard Farré
Scientific Reports 8, 5383
Research
22 March 2018 | Open Access

Artifact Rejection Methodology Enables Continuous, Noninvasive Measurement of Gastric Myoelectric Activity in Ambulatory Subjects
- Armen A. Gharibans
- , Benjamin L. Smarr
- & Todd P. Coleman
Scientific Reports 8, 5019

All Research & Reviews

News and Comment

News & Views | 13 July 2016

Rome IV criteria for FGIDs — an improvement or more of the same?

Symptom-based diagnostic criteria have been criticized for being overly complex and performing modestly in differentiating organic from functional gastrointestinal diseases. The new Rome IV criteria now supersede Rome III. In general, these minor amendments are unlikely to lead to substantial improvement in accuracy and use in routine clinical care. Is a different approach required in future?
- Ruchit Sood
- & Alexander C. Ford
Nature Reviews Gastroenterology & Hepatology 13, 501-502
News & Views | 15 September 2015

Helicobacter pylori gastritis—a novel distinct disease entity

A global consensus report on Helicobacter pylori gastritis has been developed. Topics discussed include whether dyspepsia caused by H. pylori infection is separate from functional dyspepsia or not, the evaluation method for H. pylori-induced gastritis, eradication therapy for H. pylori gastritis to prevent gastric carcinogenesis and management after H. pylori eradication.
- Hidekazu Suzuki
- & Hideki Mori
Nature Reviews Gastroenterology & Hepatology 12, 556-557
Research Highlights | 19 May 2015

Effects of antidepressants on functional dyspepsia

Nature Reviews Gastroenterology & Hepatology 12, 313
News & Views | 18 February 2014

No short cut to distinguish organic diseases from dyspepsia

Functional dyspepsia has been defined in various ways, but the diagnostic yield of these definitions has not been well validated. Ford et al. have now reported the diagnostic yield of the Rome III criteria, which was not superior to previous definitions. The study also indicates the difficulty of excluding organic diseases using these criteria.
- Hiroto Miwa
Nature Reviews Gastroenterology & Hepatology 11, 207-208
News & Views | 19 March 2013

Structural changes in functional gastrointestinal disorders

Functional gastrointestinal disorders (FGIDs) have traditionally been diagnosed on the basis of characteristic symptom patterns in the absence of organic disease that explains the symptoms. Evidence is now emerging that structural abnormalities in the brain might have a role in the pathophysiology of FGIDs.
- Emeran A. Mayer
- , Kirsten Tillisch
- & Benjamin M. Ellingson
Nature Reviews Gastroenterology & Hepatology 10, 200-202
Editorial | 06 March 2013

Glimmers of hope for functional dyspepsia
- Isobel Leake
Nature Reviews Gastroenterology & Hepatology 10, 125

All News & Comment

Functional dyspepsia articles from across Nature Portfolio

Latest Research and Reviews

Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case–control study on prepubertal Chinese boys

Duodenal acidification induces gastric relaxation and alters epithelial barrier function by a mast cell independent mechanism

Prevalence of Non-Celiac Gluten Sensitivity in Patients with Refractory Functional Dyspepsia: a Randomized Double-blind Placebo Controlled Trial

Precise and systematic survey of the efficacy of multicomponent drugs against functional dyspepsia

Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation

Artifact Rejection Methodology Enables Continuous, Noninvasive Measurement of Gastric Myoelectric Activity in Ambulatory Subjects

News and Comment

Rome IV criteria for FGIDs — an improvement or more of the same?

Helicobacter pylori gastritis—a novel distinct disease entity

Effects of antidepressants on functional dyspepsia

No short cut to distinguish organic diseases from dyspepsia

Structural changes in functional gastrointestinal disorders

Glimmers of hope for functional dyspepsia

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