Epilepsy

Epilepsy refers to a group of neurological disorders of varying aetiology, characterized by recurrent brain dysfunction that result from sudden excessive and disordered neuronal discharge. These episodes can manifest as epileptic seizures, but they can also occur with subtle or no behavioural signs.

Latest Research and Reviews

  • Research | | open

    Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses.

    • Bassel Abou-Khalil
    • , Pauls Auce
    • , Andreja Avbersek
    • , Melanie Bahlo
    • , David J. Balding
    • , Thomas Bast
    • , Larry Baum
    • , Albert J. Becker
    • , Felicitas Becker
    • , Bianca Berghuis
    • , Samuel F. Berkovic
    • , Katja E. Boysen
    • , Jonathan P. Bradfield
    • , Lawrence C. Brody
    • , Russell J. Buono
    • , Ellen Campbell
    • , Gregory D. Cascino
    • , Claudia B. Catarino
    • , Gianpiero L. Cavalleri
    • , Stacey S. Cherny
    • , Krishna Chinthapalli
    • , Alison J. Coffey
    • , Alastair Compston
    • , Antonietta Coppola
    • , Patrick Cossette
    • , John J. Craig
    • , Gerrit-Jan de Haan
    • , Peter De Jonghe
    • , Carolien G. F. de Kovel
    • , Norman Delanty
    • , Chantal Depondt
    • , Orrin Devinsky
    • , Dennis J. Dlugos
    • , Colin P. Doherty
    • , Christian E. Elger
    • , Johan G. Eriksson
    • , Thomas N. Ferraro
    • , Martha Feucht
    • , Ben Francis
    • , Andre Franke
    • , Jacqueline A. French
    • , Saskia Freytag
    • , Verena Gaus
    • , Eric B. Geller
    • , Christian Gieger
    • , Tracy Glauser
    • , Simon Glynn
    • , David B. Goldstein
    • , Hongsheng Gui
    • , Youling Guo
    • , Kevin F. Haas
    • , Hakon Hakonarson
    • , Kerstin Hallmann
    • , Sheryl Haut
    • , Erin L. Heinzen
    • , Ingo Helbig
    • , Christian Hengsbach
    • , Helle Hjalgrim
    • , Michele Iacomino
    • , Andrés Ingason
    • , Jennifer Jamnadas-Khoda
    • , Michael R. Johnson
    • , Reetta Kälviäinen
    • , Anne-Mari Kantanen
    • , Dalia Kasperavičiūte
    • , Dorothee Kasteleijn-Nolst Trenite
    • , Heidi E. Kirsch
    • , Robert C. Knowlton
    • , Bobby P. C. Koeleman
    • , Roland Krause
    • , Martin Krenn
    • , Wolfram S. Kunz
    • , Ruben Kuzniecky
    • , Patrick Kwan
    • , Dennis Lal
    • , Yu-Lung Lau
    • , Anna-Elina Lehesjoki
    • , Holger Lerche
    • , Costin Leu
    • , Wolfgang Lieb
    • , Dick Lindhout
    • , Warren D. Lo
    • , Iscia Lopes-Cendes
    • , Daniel H. Lowenstein
    • , Alberto Malovini
    • , Anthony G. Marson
    • , Thomas Mayer
    • , Mark McCormack
    • , James L. Mills
    • , Nasir Mirza
    • , Martina Moerzinger
    • , Rikke S. Møller
    • , Anne M. Molloy
    • , Hiltrud Muhle
    • , Mark Newton
    • , Ping-Wing Ng
    • , Markus M. Nöthen
    • , Peter Nürnberg
    • , Terence J. O’Brien
    • , Karen L. Oliver
    • , Aarno Palotie
    • , Faith Pangilinan
    • , Sarah Peter
    • , Slavé Petrovski
    • , Annapurna Poduri
    • , Michael Privitera
    • , Rodney Radtke
    • , Sarah Rau
    • , Philipp S. Reif
    • , Eva M. Reinthaler
    • , Felix Rosenow
    • , Josemir W. Sander
    • , Thomas Sander
    • , Theresa Scattergood
    • , Steven C. Schachter
    • , Christoph J. Schankin
    • , Ingrid E. Scheffer
    • , Bettina Schmitz
    • , Susanne Schoch
    • , Pak C. Sham
    • , Jerry J. Shih
    • , Graeme J. Sills
    • , Sanjay M. Sisodiya
    • , Lisa Slattery
    • , Alexander Smith
    • , David F. Smith
    • , Michael C. Smith
    • , Philip E. Smith
    • , Anja C. M. Sonsma
    • , Doug Speed
    • , Michael R. Sperling
    • , Bernhard J. Steinhoff
    • , Ulrich Stephani
    • , Remi Stevelink
    • , Konstantin Strauch
    • , Pasquale Striano
    • , Hans Stroink
    • , Rainer Surges
    • , K. Meng Tan
    • , Liu Lin Thio
    • , G. Neil Thomas
    • , Marian Todaro
    • , Rossana Tozzi
    • , Maria S. Vari
    • , Eileen P. G. Vining
    • , Frank Visscher
    • , Sarah von Spiczak
    • , Nicole M. Walley
    • , Yvonne G. Weber
    • , Zhi Wei
    • , Judith Weisenberg
    • , Christopher D. Whelan
    • , Peter Widdess-Walsh
    • , Markus Wolff
    • , Stefan Wolking
    • , Wanling Yang
    • , Federico Zara
    •  & Fritz Zimprich
  • Research |

    • Kohei Hamanaka
    • , Yuji Sugawara
    • , Takeyoshi Shimoji
    • , Tone Irene Nordtveit
    • , Mitsuhiro Kato
    • , Mitsuko Nakashima
    • , Hirotomo Saitsu
    • , Toshimitsu Suzuki
    • , Kazuhiro Yamakawa
    • , Ingvild Aukrust
    • , Gunnar Houge
    • , Satomi Mitsuhashi
    • , Atsushi Takata
    • , Kazuhiro Iwama
    • , Ahmed Alkanaq
    • , Atsushi Fujita
    • , Eri Imagawa
    • , Takeshi Mizuguchi
    • , Noriko Miyake
    • , Satoko Miyatake
    •  & Naomichi Matsumoto
  • Research |

    How seizures emerge in epileptic brain remains an enigma. The authors show that the transition to seizure follows a ubiquitous dynamical principle inherent to many processes in nature characterized by repeated transitions between contrasting regimes.

    • Wei-Chih Chang
    • , Jan Kudlacek
    • , Jaroslav Hlinka
    • , Jan Chvojka
    • , Michal Hadrava
    • , Vojtech Kumpost
    • , Andrew D. Powell
    • , Radek Janca
    • , Matias I. Maturana
    • , Philippa J. Karoly
    • , Dean R. Freestone
    • , Mark J. Cook
    • , Milan Palus
    • , Jakub Otahal
    • , John G. R. Jefferys
    •  & Premysl Jiruska
    Nature Neuroscience 21, 1742-1752

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