Epigenomics

Epigenomics is the systematic analysis of the global state of gene expression not attributable to mutational changes in the underlying DNA genome. An organism has multiple, cell type-specific, epigenomes comprising epigenetic marks such as DNA methylation, histone modification and specifically positioned nucleosomes.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A study in Nature Biotechnology describes single-cell genome and epigenome by transposases sequencing (scGET-seq), which generates euchromatin and heterochromatin profiles from the same cell, and Chromatin Velocity, a computational framework capable of predicting future epigenetic cell fate trajectories from scGET-seq data.

    • Dorothy Clyde
  • News & Views |

    COVID-19 has led to a global pandemic, but the long-term immunological effects of the infection are only partially understood. A new study now provides important new clues by describing the transcriptional and epigenetic processes behind the immune memory of both adaptive and innate immune cells in individuals who have recovered from COVID-19.

    • Mihai G. Netea
    •  & Yang Li
    Nature Cell Biology 23, 582-584
  • News & Views |

    Polycomb-group proteins assemble into two primary complexes—Polycomb repressive complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new studies explore the PRC1 landscape during the transition from gametes to embryos in mice, thus providing insight into the intergenerational transmission of epigenetic information and gene regulation dynamics as embryos prepare for gastrulation.

    • Julien Richard Albert
    •  & Maxim V. C. Greenberg
    Nature Genetics 53, 427-429
  • News & Views |

    The structure of chromatin is associated with its function, but precisely how is unclear. New data show that the higher-order architecture of the genome is similar among cell types with widely variant fates and gene expression patterns, thus challenging the view that chromatin domains determine function in the genome.

    • Tom Misteli
    •  & Elizabeth H. Finn
    Nature Genetics 53, 426-427