Drug screening articles within Nature Reviews Clinical Oncology

Featured

• Review Article | 12 January 2023

  Humanized mouse models for immuno-oncology research

  Preclinical models that faithfully recapitulate interactions between the human immune system and tumours are necessary to evaluate human-specific immunotherapies in vivo; however, their number is currently limited. The authors of this Review discuss the currently available humanized mouse models, which are immunodeficient mice co-engrafted with human tumours and immune components, with a focus on their applicability in translational research.

  • Jane Chuprin
  • , Hannah Buettner
  •  & Michael A. Brehm

• News & Views | 15 December 2015

  Preclinical oncology — reporting transparency needed

  Henderson and colleagues previously highlighted the need for more-rigorous standards of preclinical experimental design and reporting metrics. They now build on their earlier work with a meta-analysis of preclinical experiments that examined the efficacy of sunitinib. Their results demonstrate how suboptimal preclinical study designs can prompt unwarranted clinical expectations.

  • Eric E. Gardner
  •  & Charles M. Rudin

• Research Highlight | 11 February 2014

  High-throughput screen identifies a roadmap for combination drug trials

  • Alessia Errico