Drug discovery

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.

Featured

News & Views | 20 June 2022

Targeting drug-resistant mutations in ALK
- Liu He
- & Arvin C. Dar
Nature Cancer 3, 659-661
News & Views | 13 June 2022

Efficacy of antiangiogenic medication to treat arteriovenous malformations

Nature Cardiovascular Research 1, 552-553
News & Views | 02 June 2022

AI-powered aptamer generation
- Majid Khabbazian
- & Hosna Jabbari
Nature Computational Science 2, 356-357

Latest Research and Reviews

Research
30 June 2022 | Open Access

Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance
- Acharya Balkrishna
- , Sandeep Sinha
- & Anurag Varshney
Scientific Reports 12, 11047
Reviews
30 June 2022 | Open Access

Targeting fibrosis, mechanisms and cilinical trials
- Manyu Zhao
- , Liqun Wang
- & Yuqin Yao
Signal Transduction and Targeted Therapy 7, 206
Research
30 June 2022 | Open Access

Comparative transcriptome analysis reveals the resistance regulation mechanism and fungicidal activity of the fungicide phenamacril in Fusarium oxysporum
- Zhitian Zheng
- , Huaqi Liu
- & Feng Zhang
Scientific Reports 12, 11081
Research
30 June 2022 | Open Access

A phase 1b study of andecaliximab in combination with S-1 plus platinum in Japanese patients with gastric adenocarcinoma
- Akira Ooki
- , Taroh Satoh
- & Kensei Yamaguchi
Scientific Reports 12, 11007
Research
30 June 2022 | Open Access

Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells
- Siti Farah Rahmawati
- , Rémon Vos
- & Reinoud Gosens
Scientific Reports 12, 11110
Research
30 June 2022 | Open Access

Identification of bioactive peptides from a Brazilian kefir sample, and their anti-Alzheimer potential in Drosophila melanogaster
- Serena Mares Malta
- , Letícia Leandro Batista
- & Carlos Ueira-Vieira
Scientific Reports 12, 11065

All Research & Reviews

News and Comment

News | 29 June 2022

COVID antibody drugs have saved lives — so why aren’t they more popular?

Drugs made from antibodies are huge money-makers for some conditions — but they have gained little traction in infectious diseases, including COVID.
- Asher Mullard
Nature 606, 854-856
Correspondence | 22 June 2022

The show must go on. Reply to “Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al” by Insop Shim
- Jordi Bonaventura
- , Sherry Lam
- & Michael Michaelides
Molecular Psychiatry, 1-2
News & Views | 20 June 2022

Targeting drug-resistant mutations in ALK

Therapy resistance limits the clinical success of tyrosine kinase inhibitors (TKIs) in ALK-positive non-small cell lung cancer. A study now proposes a framework to identify compound resistance mutations to the lorlatinib TKI and provides structure-based drug design approaches to overcome resistance mediated by ALK(G1202R) or ALK(I1171N/S/T).
- Liu He
- & Arvin C. Dar
Nature Cancer 3, 659-661
News & Views | 13 June 2022

Efficacy of antiangiogenic medication to treat arteriovenous malformations

In a prospective experimental observational study of 18 individuals with severe, recurrent extracranial arteriovenous malformations, thalidomide was effective in reducing pain, healing ulceration, stopping bleeding and resolving cardiac failure.

Nature Cardiovascular Research 1, 552-553
News | 13 June 2022

New COVID drugs face delays as trials grow more difficult

Fewer people are eligible for the massive studies needed to test treatments for severe COVID-19.
- Saima May Sidik
Nature 606, 637
Research Highlights | 09 June 2022

Vaccine exposes tumours to immune cell attack
- M. Teresa Villanueva
Nature Reviews Drug Discovery

All News & Comment

Drug discovery

Featured

Targeting drug-resistant mutations in ALK

Efficacy of antiangiogenic medication to treat arteriovenous malformations

AI-powered aptamer generation

Latest Research and Reviews

Withania somnifera (L.) Dunal whole-plant extract demonstrates acceptable non-clinical safety in rat 28-day subacute toxicity evaluation under GLP-compliance

Targeting fibrosis, mechanisms and cilinical trials

Comparative transcriptome analysis reveals the resistance regulation mechanism and fungicidal activity of the fungicide phenamacril in Fusarium oxysporum

A phase 1b study of andecaliximab in combination with S-1 plus platinum in Japanese patients with gastric adenocarcinoma

Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells

Identification of bioactive peptides from a Brazilian kefir sample, and their anti-Alzheimer potential in Drosophila melanogaster

News and Comment

COVID antibody drugs have saved lives — so why aren’t they more popular?

The show must go on. Reply to “Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al” by Insop Shim

Targeting drug-resistant mutations in ALK

Efficacy of antiangiogenic medication to treat arteriovenous malformations

New COVID drugs face delays as trials grow more difficult

Vaccine exposes tumours to immune cell attack

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