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| Open AccessA novel scaffold for EGFR inhibition: Introducing N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives
- Daniel Nascimento do Amaral
- , Jonas Lategahn
- & Lidia Moreira Lima
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| Open AccessErgosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells
- Han-Ying Wu
- , Feng-Ling Yang
- & Shih-Hsiung Wu
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| Open AccessUltrasound mediated accelerated Anti-influenza activity of Aloe vera
- Enkhtaivan Gansukh
- , Judy Gopal
- & Sechul Chun
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| Open AccessTernary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction
- Masato Noguchi
- , Akihiro Nomura
- & Tsuyoshi Adachi
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| Open AccessStructure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus
- Jin-Cherng Lien
- , Ching-Ying Wang
- & Cheng-Wen Lin
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| Open AccessDehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1
- Laura E. Kolsi
- , Ana S. Leal
- & Vânia M. Moreira
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| Open AccessInsights into gold nanoparticles as a mucoadhesive system
- Mathieu Ouellette
- , Florence Masse
- & Élodie Boisselier
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| Open AccessPharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
- Norihito Shibata
- , Kenichiro Shimokawa
- & Mikihiko Naito
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| Open AccessNovel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1
- Adrian Richter
- , Ines Rudolph
- & Argyrides Argyrou
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| Open AccessIron(III)-Tannic Molecular Nanoparticles Enhance Autophagy effect and T1 MRI Contrast in Liver Cell Lines
- Krungchanuchat Saowalak
- , Thongtem Titipun
- & Pilapong Chalermchai
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| Open AccessHigh throughput evaluation of macrocyclization strategies for conformer stabilization
- Dan Sindhikara
- & Ken Borrelli
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| Open AccessMaresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression
- Natsuko Saito-Sasaki
- , Yu Sawada
- & Motonobu Nakamura
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| Open AccessPorphyrins inactivate Nosema spp. microsporidia
- Aneta A. Ptaszyńska
- , Mariusz Trytek
- & Dorota Gryko
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| Open AccessStructure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs
- Kai Ding
- , Ziyuan Zhou
- & Chang-Guo Zhan
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| Open AccessExploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance
- Jiantao Zhang
- , Yanmei Hu
- & Jun Wang
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| Open AccessIn silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase
- Salvatore Ferla
- , Natalie E. Netzler
- & Marcella Bassetto
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| Open AccessEvaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe
- Hadis Honarvar
- , Enrica Calce
- & Stefania De Luca
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| Open AccessIn vitro cytotoxicity activity of novel Schiff base ligand–lanthanide complexes
- Kavitha Andiappan
- , Anandhavelu Sanmugam
- & Dhanasekaran Vikraman
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| Open AccessElectrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships
- Nicholas K. H. Khoo
- , Lihua Li
- & Bruce A. Freeman
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| Open AccessApplication of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi
- Xiao-Fei Shang
- , Ying-Qian Liu
- & Xiao-Shuai Zhang
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| Open AccessAnalogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
- Cynthia A. Danquah
- , Eleftheria Kakagianni
- & Simon Gibbons
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| Open AccessNew generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activity
- Hadi Zare-Zardini
- , Asghar Taheri-Kafrani
- & Abdol-Khalegh Bordbar
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| Open AccessPolypharmacy through Phage Display: Selection of Glucagon and GLP-1 Receptor Co-agonists from a Phage-Displayed Peptide Library
- Anna Demartis
- , Armin Lahm
- & Antonello Pessi
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| Open AccessNew anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421
- Siwen Niu
- , Chun-Lan Xie
- & Xian-Wen Yang
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| Open AccessAnti-glioma Natural Products Downregulating Tumor Glycolytic Enzymes from Marine Actinomycete Streptomyces sp. ZZ406
- Mengxuan Chen
- , Weiyun Chai
- & Zhizhen Zhang
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| Open AccessIdentification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
- Allison E. Drew
- , Oscar Moradei
- & Scott A. Ribich
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| Open AccessComputational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases
- Matteo Santucci
- , Francesca Spyrakis
- & Maria Paola Costi
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| Open AccessDesign and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors
- Yue Wu
- , Dongjie Feng
- & Weige Zhang
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| Open AccessSecond messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”
- Joanna M. Watt
- , Richard Graeff
- & Barry V. L. Potter
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| Open AccessA new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma
- Yang Zhang
- , Yinfang Wu
- & Huahao Shen
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| Open AccessNovel serotonin transporter regulators: Natural aristolane- and nardosinane- types of sesquiterpenoids from Nardostachys chinensis Batal
- Ying-Peng Chen
- , Shu-Song Ying
- & Hong-Hua Wu
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| Open AccessCombating virulence of Gram-negative bacilli by OmpA inhibition
- Xavier Vila-Farrés
- , Raquel Parra-Millán
- & Younes Smani
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| Open AccessNovel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes
- Sabina Yasmin
- , Fabio Capone
- & Antonio Lavecchia
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| Open AccessRegiospecific Synthesis of Ring A Fused Withaferin A Isoxazoline Analogues: Induction of Premature Senescence by W-2b in Proliferating Cancer Cells
- Faheem Rasool
- , Debasis Nayak
- & Debaraj Mukherjee
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| Open AccessA self-feedback network based on liquid chromatography-quadrupole-time of flight mass spectrometry for system identification of β-carboline alkaloids in Picrasma quassioides
- Yuanyuan Shi
- , Ruoqi Wang
- & Feng Feng
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| Open AccessArginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities
- Jérémie Mortier
- , Julien R. C. Prévost
- & Gerhard Wolber
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| Open AccessGRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro
- Masayuki Amano
- , Pedro Miguel Salcedo-Gómez
- & Hiroaki Mitsuya
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| Open AccessA Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions
- Simona Rapposelli
- , Laura Gambari
- & Francesco Grassi
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| Open AccessCytochalasan and Tyrosine-Derived Alkaloids from the Marine Sediment-Derived Fungus
Westerdykella dispersa and Their Bioactivities- Dan Xu
- , Minghe Luo
- & Xiaolong Yang
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| Open AccessA synthetic cell permeable antioxidant protects neurons against acute oxidative stress
- Nicola J. Drummond
- , Nick O. Davies
- & Tilo Kunath
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| Open AccessDiscovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives
- Xue-Qing Zhang
- , Carmenza Spadafora
- & Chang-Lun Shao
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| Open AccessNovel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach
- Andrea R. Beccari
- , Marica Gemei
- & Giulio Vistoli
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| Open AccessDevelopment of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
- Jhonny Azuaje
- , Paula López
- & Eddy Sotelo
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| Open AccessIdentification of the protective mechanisms of Lactoferrin in the irradiated salivary gland
- Manabu Sakai
- , Takumi Matsushita
- & Takayoshi Sakai
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| Open AccessA clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”
- Hiroshi Tateishi
- , Kazuaki Monde
- & Mikako Fujita
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| Open AccessSynthesis of Sulfo-Sialic Acid Analogues: Potent Neuraminidase Inhibitors in Regards to Anomeric Functionality
- Christopher J. Vavricka
- , Chiaki Muto
- & Hiromasa Kiyota
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| Open AccessIdentification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents
- C. Zamperini
- , G. Maccari
- & M. Botta
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| Open AccessTargeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer
- Safiulla Basha Syed
- , Hemant Arya
- & Mohane Selvaraj Coumar
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| Open AccessXylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102)
- Wei-Feng Xu
- , Xue-Mei Hou
- & Chang-Lun Shao