| Open Access
Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2
Heather Gardner et al. report the genomic landscape of canine osteosarcoma, finding recurrent mutations in the histone methyltransferase gene SETD2 and in DMD, the gene encoding dystrophin. The results support the study of naturally-occurring osteosarcoma in dogs for understanding both human disease mechanisms and canine-specific alterations to identify new treatments.