Dog

The domestic dog, Canis familiaris, is a canid mammal that has been bred to produce a large number of varieties with diverse characteristics, enabling the study of breeding and the genetics underlying many traits and diseases.

Latest Research and Reviews

  • Research
    | Open Access

    Heather Gardner et al. report the genomic landscape of canine osteosarcoma, finding recurrent mutations in the histone methyltransferase gene SETD2 and in DMD, the gene encoding dystrophin. The results support the study of naturally-occurring osteosarcoma in dogs for understanding both human disease mechanisms and canine-specific alterations to identify new treatments.

    • Heather L. Gardner
    • , Karthigayini Sivaprakasam
    • , Natalia Briones
    • , Victoria Zismann
    • , Nieves Perdigones
    • , Kevin Drenner
    • , Salvatore Facista
    • , Ryan Richholt
    • , Winnie Liang
    • , Jessica Aldrich
    • , Jeffrey M. Trent
    • , Peter G. Shields
    • , Nicholas Robinson
    • , Jeremy Johnson
    • , Susan Lana
    • , Peter Houghton
    • , Joelle Fenger
    • , Gwendolen Lorch
    • , Katherine A. Janeway
    • , Cheryl A. London
    •  & William P. D. Hendricks
  • Reviews |

    Osteoarthritis occurs spontaneously in pet dogs, which often share environmental and lifestyle risk-factors with their owners. This Review aims to stimulate cooperation between medical and veterinary research under the One Medicine initiative to improve the welfare of dogs and humans.

    • Richard L. Meeson
    • , Rory J. Todhunter
    • , Gordon Blunn
    • , George Nuki
    •  & Andrew A. Pitsillides
  • Reviews |

    Despite being a single species, dogs represent nearly 400 breeds with substantial genetic, morphological and behavioural diversity. In this Review, Ostranderet al. discuss how genomics studies of dogs have enhanced our understanding of dog and human population history, the desired and unintended consequences of trait-based selective breeding, and potentially human-applicable insights into cancer, ageing, behaviour and neurological diseases.

    • Elaine A. Ostrander
    • , Robert K. Wayne
    • , Adam H. Freedman
    •  & Brian W. Davis
  • Research |

    An extensive genome-wide survey of over 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf, was conducted to shed light on the process of dog diversification. The results reveal that much of genome diversity came from Middle Eastern progenitors, combined with interbreeding with local wolf populations, and that recent evolution involved limited genetic variation to create the phenotypic diversity of modern dogs.

    • Bridgett M. vonHoldt
    • , John P. Pollinger
    • , Kirk E. Lohmueller
    • , Eunjung Han
    • , Heidi G. Parker
    • , Pascale Quignon
    • , Jeremiah D. Degenhardt
    • , Adam R. Boyko
    • , Dent A. Earl
    • , Adam Auton
    • , Andy Reynolds
    • , Kasia Bryc
    • , Abra Brisbin
    • , James C. Knowles
    • , Dana S. Mosher
    • , Tyrone C. Spady
    • , Abdel Elkahloun
    • , Eli Geffen
    • , Malgorzata Pilot
    • , Wlodzimierz Jedrzejewski
    • , Claudia Greco
    • , Ettore Randi
    • , Danika Bannasch
    • , Alan Wilton
    • , Jeremy Shearman
    • , Marco Musiani
    • , Michelle Cargill
    • , Paul G. Jones
    • , Zuwei Qian
    • , Wei Huang
    • , Zhao-Li Ding
    • , Ya-ping Zhang
    • , Carlos D. Bustamante
    • , Elaine A. Ostrander
    • , John Novembre
    •  & Robert K. Wayne
    Nature 464, 898-902

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