Diffusion tensor imaging

Accurate structural brain connectivity estimation is key to uncovering brain–behavior relationships. ReAl-LiFE, a GPU-accelerated approach, is applied for fast and reliable evaluation of individualized brain connectomes at scale.

Hong-Hsi Lee et al. identify a characteristic power-law scaling in the time-dependent diffusion MRI signal that can detect micrometer-scale variations in axon caliber or pathological beading. They validate this signature trait using Monte Carlo simulations in axonal microstructure based on electron microscopy of mouse corpus callosum and illustrate the sensitivity of this method by detecting axon beading in a neurodegenerative disorder.