Data processing articles from across Nature Portfolio

Analysing the regulatory consequences of mutations and splice variants at large scale in cancer requires efficient computational tools. Here, the authors develop RegTools, a software package that can identify splice-associated variants from large-scale genomics and transcriptomics data with efficiency and flexibility.

High-resolution in situ protein structure can be solved by cryo-ET, which requires several days of data collection. Here Cheng et al. report GisSPA, a program that may enable determining sub-4 Å resolution structures on cellular lamellae within one day of data collection.

Deep-Manager is a software platform that enables efficient selection of features with lower sensitivity to unspecified disturbances across sets of similar experiments in bioimaging.

scPrisma deconvolutes different biological processes in single-cell RNA-sequencing data.

Integration of metagenomic assemblies and microbial isolate genomes improves profiling of uncharacterized species.