Cytokinesis

Cytokinesis occurs after nuclear division and is the process that divides the cytoplasm to give rise to two new cells, each with one set of chromosomes. Cytokinesis begins with the contraction of the cell equator and ends with severing the remaining connection between the daughter cells.

Latest Research and Reviews

  • Research
    | Open Access

    ESCRT filaments drive the final abscission between two daughter cells but how they physically interact with the membrane is unclear. Using proteomics, the authors show that syndecan-4/syntenin/ALIX couples the ESCRT machinery to the abscission site and thus promotes efficient abscission.

    • Cyril Addi
    • , Adrien Presle
    • , Stéphane Frémont
    • , Frédérique Cuvelier
    • , Murielle Rocancourt
    • , Florine Milin
    • , Sandrine Schmutz
    • , Julia Chamot-Rooke
    • , Thibaut Douché
    • , Magalie Duchateau
    • , Quentin Giai Gianetto
    • , Audrey Salles
    • , Hervé Ménager
    • , Mariette Matondo
    • , Pascale Zimmermann
    • , Neetu Gupta-Rossi
    •  & Arnaud Echard
  • Research
    | Open Access

    In mammalian cell lines, Cep55 protein recruits the endosomal sorting complex required for transport (ESCRT) and promotes the completion of cell division. Here, the authors show that Cep55-knockout mice are viable and primary fibroblasts cultured in vitro divide in a Cep55 and ESCRT-independent way.

    • Antonio Tedeschi
    • , Jorge Almagro
    • , Matthew J. Renshaw
    • , Hendrik A. Messal
    • , Axel Behrens
    •  & Mark Petronczki
  • Reviews |

    During cell division, the distribution of membrane-bound organelles needs to be tightly regulated to ensure the proper composition and function of daughter cells. Recent studies have shed light on the range of complex and dynamic mechanisms needed to mediate organelle inheritance and membrane remodelling during cell division.

    • Jeremy G. Carlton
    • , Hannah Jones
    •  & Ulrike S. Eggert
  • Research |

    The use of an in vitro system in which key proteins involved in cell division are attached to supported lipid bilayers reveals that membrane-bound cytosolic peptides of FtsN and FtsQ co-migrate with treadmilling FtsZ–FtsA filaments via a diffusion-and-capture mechanism, elucidating how FtsZ dynamics regulate the distribution of peptidoglycan synthases.

    • Natalia Baranova
    • , Philipp Radler
    • , Víctor M. Hernández-Rocamora
    • , Carlos Alfonso
    • , Mar López-Pelegrín
    • , Germán Rivas
    • , Waldemar Vollmer
    •  & Martin Loose
    Nature Microbiology 5, 407-417
  • Reviews |

    Endosomal sorting complexes required for transport (ESCRTs) are key membrane remodellers, which drive the budding, scission and sealing of various cellular membranes. Accordingly, ongoing research focuses on how ESCRTs mediate a wide-range of cellular processes, including cytokinesis, endosome maturation, autophagy, membrane repair and viral replication.

    • Marina Vietri
    • , Maja Radulovic
    •  & Harald Stenmark

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