Cross-coupling reactions

Cross-coupling reactions are those in which two different starting materials, each of which is usually endowed with an activating group, are reacted together with the aid of a metal catalyst. The result is the loss of the two activating groups and the formation of a new covalent bond between the remaining fragments.

Latest Research and Reviews

News and Comment

  • News & Views |

    Methods for the direct one-step replacement of a hydrogen atom in a C–H bond by an organic functional group can create enormous possibilities for synthetic applications. On the way to solve this challenge, the discovery of the reaction of organopalladium complexes with olefins opened a new era in catalysis and organic chemistry.

    • Valentine P. Ananikov
    Nature Catalysis 4, 732-733
  • Research Highlights |

    Selective cross-coupling at either of two similar halide substituents in a dihalogenated substrate can be achieved by controlling the speciation of the active palladium catalyst.

    • Jamal A. Malik
  • Research Highlights |

    Air-stable nickel precatalysts enable one to rapidly screen ligands, organic substrates and conditions in an accessible and scalable fashion. The best method can be identified and translated to an industrial setting.

    • David Schilter
  • Comments & Opinion |

    Radical intermediates are key species in many chemical transformations. Recent advances have provided a new suite of selective radical alkylation reactions. This Comment highlights pioneering studies using alkyl amines that act as radical precursors in a number of catalytic processes by their conversion to alkylpyridinium salts.

    • Duanyang Kong
    • , Patrick J. Moon
    •  & Rylan J. Lundgren
    Nature Catalysis 2, 473-476