Chemokines articles from across Nature Portfolio

Chemokines are a class of cytokine protein that act as signalling molecules, regulating immune and inflammatory responses; for example, modulating cell migration properties and localization of target cells such as leucokytes. The biological functions of chemokines are typically mediated by signalling through G protein-coupled chemokine receptors.

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News & Views | 22 May 2023

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

Nature Immunology, 1-2

Latest Research and Reviews

Reviews
19 May 2023 | Open Access

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis
- Teizo Yoshimura
- , Chunning Li
- & Akihiro Matsukawa
Cellular & Molecular Immunology, 1-25
Research
18 May 2023 | Open Access

Conserved stromal–immune cell circuits secure B cell homeostasis and function

Pikor et al. show that a set of conserved, bidirectional cues exchanged between fibroblastic reticular cells and immune cells sustain B cell niches, which control humoral immune responses across mouse and human lymphoid organs.
- Mechthild Lütge
- , Angelina De Martin
- & Natalia B. Pikor
Nature Immunology, 1-12
Reviews
17 May 2023 | Open Access

New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine
- Hanli Xu
- , Shuye Lin
- & Jiaqiang Huang
Cellular & Molecular Immunology, 1-38
Research
29 April 2023 | Open Access

Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial
- C. H. Leung
- , S. B. Rizoli
- & O. D. Rotstein
Scientific Reports 13, 7025
Research | 17 April 2023

ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors

CAR T cell success requires targeting tumors, but these cells can get trapped in other tissues, such as in the lungs, where they can cause pathology. Here, the authors use a loss-of-function CRISPR screen to identify regulators of CAR T cell tumor trafficking and engineer CAR T cells accordingly to overcome this limitation.
- Yeonsun Hong
- , Brandon L. Walling
- & Minsoo Kim
Nature Immunology, 1-13
Research
14 April 2023 | Open Access

Priming a vascular-selective cytokine response permits CD8⁺ T-cell entry into tumors

It has been reported that inhibition of the epigenetic regulator DNA methyltransferase 1 (DNMT1) is associated with improved response to immune checkpoint blockade (ICB). Here the authors show that conditional deletion of Dnmt1 in endothelial cells is sufficient to promote T cell infiltration, reduce tumor growth and enhance ICB response in preclinical models.
- Dae Joong Kim
- , Swetha Anandh
- & Andrew C. Dudley
Nature Communications 14, 2122

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News and Comment

News & Views | 22 May 2023

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (T_FH) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses.

Nature Immunology, 1-2
News & Views | 15 March 2023

The kinetics of chemokine autoantibodies in COVID-19

Several panels of naturally arising antibodies against specific chemokines are closely correlated with various favorable COVID-19 outcomes, raising an opportunity to target the chemokine system for long COVID treatment.
- Furong Qi
- , Dapeng Li
- & Zheng Zhang
Nature Immunology 24, 567-569
Research Highlights | 14 March 2023

CXCL8 blockade reduces fibrosis in endometriosis
- Yvonne Bordon
Nature Reviews Immunology 23, 203
Research Highlights | 14 March 2023

Autoantibodies against chemokines linked with better disease outcomes in COVID-19
- Yvonne Bordon
Nature Reviews Immunology 23, 203
Research Highlights | 16 November 2022

Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells
- Xinping Lv
- , Shan Zhu
- & Jingtao Chen
Cellular & Molecular Immunology 20, 115-116
Research Highlights | 02 November 2022

CXCL5 effective in mouse model of SLE

In a mouse model of lupus, treatment with CXCL5 reduces disease activity and promotes survival.
- Robert Phillips
Nature Reviews Rheumatology 18, 673

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Chemokines articles from across Nature Portfolio

Featured

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

Latest Research and Reviews

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

Conserved stromal–immune cell circuits secure B cell homeostasis and function

New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine

Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial

ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors

Priming a vascular-selective cytokine response permits CD8⁺ T-cell entry into tumors

News and Comment

Aberrant distribution of T_FH cells in aged germinal centers reduces stromal cell function

The kinetics of chemokine autoantibodies in COVID-19

CXCL8 blockade reduces fibrosis in endometriosis

Autoantibodies against chemokines linked with better disease outcomes in COVID-19

Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells

CXCL5 effective in mouse model of SLE

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