CD8-positive T cells

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous or virally infected cells, and CD8-positive suppressor T cells, which restrain certain types of immune response.

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News & Views | 30 January 2023

CD8⁺ T cells pass the acid test
- Ju Hee Oh
- , Anne-Sophie Archambault
- & Ramon I. Klein Geltink
Nature Metabolism, 1-2
News & Views | 23 January 2023

CD8⁺ T cell depletion does not induce an expansion of viral reservoir in HIV model

Nature Microbiology 8, 191-192

Latest Research and Reviews

Research | 02 February 2023

Phosphoinositide acyl chain saturation drives CD8⁺ effector T cell signaling and function

Here the authors show how metabolic alteration of acyl chain composition affects phosphoinositide-driven signaling to initiate and sustain CD8⁺ T cell effector function during cell differentiation.
- Joy Edwards-Hicks
- , Petya Apostolova
- & Erika L. Pearce
Nature Immunology, 1-15
Research
30 January 2023 | Open Access

CD8⁺ CD226^high T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery
- Julien Viot
- , Syrine Abdeljaoued
- & Marie Kroemer
Cellular & Molecular Immunology, 1-14
Research
30 January 2023 | Open Access

Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness

Prolonged exposure to acid is shown to reprogram T cell intracellular methionine metabolism to preserve T cell stemness and increase anti-tumor efficacy.
- Hongcheng Cheng
- , Yajing Qiu
- & Guideng Li
Nature Metabolism, 1-17
Research
19 January 2023 | Open Access

IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells

IFN-γ is associated with the efficacy of anti-tumour immune responses, and both pro- and anti-tumour functions have been ascribed to this cytokine. Here, the authors demonstrate that IFN-γ signalling inhibits the maintenance of stem-like T cells, thereby impairing anti-tumour immune responses.
- Julie M. Mazet
- , Jagdish N. Mahale
- & Audrey Gérard
Nature Communications 14, 321
Research
19 January 2023 | Open Access

Cytotoxic CD8⁺ T cells target citrullinated antigens in rheumatoid arthritis

The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.
- Jae-Seung Moon
- , Shady Younis
- & William H. Robinson
Nature Communications 14, 319
Research
04 January 2023 | Open Access

IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis
- Martyna Scibiorek
- , Nontobeko Mthembu
- & Sabelo Hadebe
Scientific Reports 13, 144

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News and Comment

News & Views | 30 January 2023

CD8⁺ T cells pass the acid test

Lactate build up in the tumour microenvironments is thought to dampen anti-tumour immunity, but in vitro pre-conditioning T cells with lactate enhances anti-tumour activity in vivo in pre-clinical mouse models.
- Ju Hee Oh
- , Anne-Sophie Archambault
- & Ramon I. Klein Geltink
Nature Metabolism, 1-2
Research Highlights | 27 January 2023

Co-stimulation needed in the tumor
- Nicholas J. Bernard
Nature Immunology 24, 204
News & Views | 23 January 2023

CD8⁺ T cell depletion does not induce an expansion of viral reservoir in HIV model

Cytotoxic CD8⁺ T cells reduce the average lifespan of productively infected cells during acute simian immunodeficiency virus infection (a primate model of human immunodeficiency virus infection). However, they are ineffective at preventing the establishment of a persistent reservoir of latently infected cells under long-term antiretroviral therapy.

Nature Microbiology 8, 191-192
Research Highlights | 03 January 2023

Immunotherapy response
- Nicholas J. Bernard
Nature Immunology 24, 2
Research Highlights | 03 January 2023

STAT5A antagonizes TOX in CD8⁺ T cell exhaustion

A preprint by Beltra et al. describes a role for STAT5A in the development of an intermediate-exhausted ‘effector-like’ phenotype of exhausted T cells.
- David Arcia-Anaya
- & Tim Elliott
Nature Reviews Immunology 23, 73
Research Highlights | 30 November 2022

α-Myosin-specific CD8⁺ T cells drive ICI-related myocarditis

Cytotoxic CD8⁺ T cells specific for the cardiac protein α-myosin heavy chain have a key role in immune-checkpoint-inhibitor-associated myocarditis, according to a study published in Nature.
- Irene Fernández-Ruiz
Nature Reviews Cardiology 20, 75

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CD8-positive T cells

Featured

CD8⁺ T cells pass the acid test

CD8⁺ T cell depletion does not induce an expansion of viral reservoir in HIV model

Latest Research and Reviews

Phosphoinositide acyl chain saturation drives CD8⁺ effector T cell signaling and function

CD8⁺ CD226^high T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery

Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness

IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells

Cytotoxic CD8⁺ T cells target citrullinated antigens in rheumatoid arthritis

IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis

News and Comment

CD8⁺ T cells pass the acid test

Co-stimulation needed in the tumor

CD8⁺ T cell depletion does not induce an expansion of viral reservoir in HIV model

Immunotherapy response

STAT5A antagonizes TOX in CD8⁺ T cell exhaustion

α-Myosin-specific CD8⁺ T cells drive ICI-related myocarditis

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CD8-positive T cells

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