Catalytic DNA articles from across Nature Portfolio

Catalytic DNA (deoxyribonucleic acid) are single-stranded DNA molecules with enzyme activity, for instance in cleaving RNA. Binding of catalytic DNA to its RNA targets is generally by Watson–Crick base pairing. Catalytic DNA can also target proteins and DNA with a range of outcomes, for instance as a peroxidase. Non-natural catalytic DNA molecules have been designed or discovered.

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News and Comment

  • News & Views |

    A synthetic DNA enzyme catalyses the formation of a native phosphodiester bond between two RNA fragments, but the molecular details of the mechanism remained elusive. Research using computational and biochemical approaches now suggests that the DNA enzyme recruits two magnesium ions to assist in the catalysis of RNA ligation.

    • Claudia Höbartner
    Nature Catalysis 2, 483-484