Cardiovascular genetics articles within Nature Genetics

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• Article | 14 November 2010

  Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

  Nona Sotoodehnia and colleagues report a meta-analysis of 14 genome-wide association studies for QRS interval, an electrocardiogram measurement of cardiac ventricular conduction. They identify 22 loci associated with QRS duration.

  • Nona Sotoodehnia
  • , Aaron Isaacs
  •  & Dan E Arking

• Letter | 10 January 2010

  Genetic variation in SCN10A influences cardiac conduction

  John Chambers and colleagues report genome-wide association studies to several ECG measurements, identifying an association of SCN10A to PR interval. They find that Scn10a^−/− mice show a shorter PR interval.

  • John C Chambers
  • , Jing Zhao
  •  & Jaspal S Kooner

• Letter | 10 January 2010

  Genome-wide association study of PR interval

  Arne Pfeufer and colleagues report a genome-wide association study of the electrocardiographic measurement of PR interval in seven population-based cohorts in the CHARGE consortium. They identify nine loci associated with PR interval and highlight candidate genes with a role in ion channels and cardiac development.

  • Arne Pfeufer
  • , Charlotte van Noord
  •  & Susan R Heckbert