Featured
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Article
| Open AccessDiagnostic yield and clinical relevance of expanded germline genetic testing for nearly 7000 suspected HBOC patients
- Jan Henkel
- , Andreas Laner
- & Elke Holinski-Feder
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Article
| Open AccessClinical case study meets population cohort: identification of a BRCA1 pathogenic founder variant in Orcadians
- Shona M. Kerr
- , Emma Cowan
- & Zosia Miedzybrodzka
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Article
| Open AccessFANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women
- Gisella Figlioli
- , Amandine Billaud
- & Paolo Peterlongo
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Article |
Variable number tandem repeats (VNTRs) as modifiers of breast cancer risk in carriers of BRCA1 185delAG
- Yuan Chun Ding
- , Aaron W. Adamson
- & Susan L. Neuhausen
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Article |
Prevalent versus incident breast cancers: benefits of clinical and radiological monitoring in women with pathogenic BRCA1/2 variants
- Claire Saule
- , Solveig Menu-Hespel
- & Emmanuelle Mouret-Fourme
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Article |
Two distinct mechanisms underlie estrogen-receptor-negative breast cancer susceptibility at the 2p23.2 locus
- Gustavo Mendoza-Fandiño
- , Paulo Cilas M. Lyra Jr
- & Alvaro N. A. Monteiro
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Article |
Mainstream genetic testing for breast cancer patients: early experiences from the Parkville Familial Cancer Centre
- Catherine Beard
- , Katrina Monohan
- & Paul A. James
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Article |
Intrafamilial communication of hereditary breast and ovarian cancer genetic information in Italian women: towards a personalised approach
- Maria Luisa Di Pietro
- , Drieda Zaçe
- & Maurizio Genuardi
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Article
| Open AccessThe intronic BRCA1 c.5407-25T>A variant causing partly skipping of exon 23—a likely pathogenic variant with reduced penetrance?
- Hildegunn Høberg-Vetti
- , Elisabet Ognedal
- & Per Morten Knappskog
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Brief Communication |
Assessing the effectiveness of NICE criteria for stratifying breast cancer risk in a UK cohort
- Lucy A. Littlejohn
- , Jim Gibbs
- & Jonathan N. Berg
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Article |
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers
- Lisa Golmard
- , Laurent Castéra
- & Claude Houdayer
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Article |
Detecting splicing patterns in genes involved in hereditary breast and ovarian cancer
- Grégoire Davy
- , Antoine Rousselin
- & Sophie Krieger
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Article
| Open AccessEvaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers
- Logan C Walker
- , Louise Marquart
- & Amanda B Spurdle
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Review
| Open AccessNew challenges for BRCA testing: a view from the diagnostic laboratory
- Andrew J Wallace
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Article |
A family-based, genome-wide association study of young-onset breast cancer: inherited variants and maternally mediated effects
- Katie M O'Brien
- , Min Shi
- & Clarice R Weinberg
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Article
| Open AccessBRCA1/2 testing in newly diagnosed breast and ovarian cancer patients without prior genetic counselling: the DNA-BONus study
- Hildegunn Høberg-Vetti
- , Cathrine Bjorvatn
- & Nicoline Hoogerbrugge
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Article |
C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients
- Mutsuko Yamamoto-Ibusuki
- , Yutaka Yamamoto
- & Hirotaka Iwase
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Article
| Open AccessEvaluation of the Dutch BRCA1/2 clinical genetic center referral criteria in an unselected early breast cancer population
- Alexandra J van den Broek
- , Karen de Ruiter
- & Marjanka K Schmidt
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Article |
Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes
- Laurent Castéra
- , Sophie Krieger
- & Dominique Vaur
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News and Commentary |
Do BRCA1/2 mutations and low FMR1 alleles interact or not?
- Norbert Gleicher
- , Andrea Weghofer
- & David H Barad
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Short Report |
The FMR1 CGG repeat test is not a candidate prescreening tool for identifying women with a high probability of being carriers of BRCA mutations
- Maria Teresa Ricci
- , Loredana Pennese
- & Liliana Varesco
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Article |
CHEK2*1100delC homozygosity in the Netherlands—prevalence and risk of breast and lung cancer
- Petra EA Huijts
- , Antoinette Hollestelle
- & Christi J van Asperen
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Article |
PGD for hereditary breast and ovarian cancer: the route to universal tests for BRCA1 and BRCA2 mutation carriers
- Marion Drüsedau
- , Jos C Dreesen
- & Aimée D Paulussen
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Article |
Comparison of genetic variation of breast cancer susceptibility genes in Chinese and German populations
- David Barzan
- , Marlon R Veldwijk
- & Frederik Wenz
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Article
| Open AccessExploring resources for intrafamilial communication of cancer genetic risk: we still need to talk
- Kelly A McClellan
- , Erika Kleiderman
- & Denise Avard
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Article |
Angiogenetic axis angiopoietins/Tie2 and VEGF in familial breast cancer
- K Danza
- , B Pilato
- & S Tommasi
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Short Report |
Low prevalence of SLX4 loss-of-function mutations in non-BRCA1/2 breast and/or ovarian cancer families
- Gorka Ruiz de Garibay
- , Avellaneda Díaz
- & Miguel de la Hoya
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Article |
A focus group study on breast cancer risk presentation: one format does not fit all
- Michel Dorval
- , Karine Bouchard
- & Jacques Simard
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Article
| Open AccessPersonalized medicine and access to health care: potential for inequitable access?
- Kelly A McClellan
- , Denise Avard
- & Bartha M Knoppers
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Article
| Open AccessA two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility
- Yadav Sapkota
- , Paula Robson
- & Sambasivarao Damaraju
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Article |
Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers
- Brandie Heald
- , Emily Edelman
- & Charis Eng
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Short Report |
Gene and genetic diagnostic method patent claims: a comparison under current European and US patent law
- Isabelle Huys
- , Geertrui Van Overwalle
- & Gert Matthijs
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Article |
Breast and ovarian cancer screening of non-carriers from BRCA1/2 mutation-positive families: 2-year follow-up of cohorts from France and Quebec
- Michel Dorval
- , Catherine Noguès
- & Claire Julian-Reynier
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Short Report |
Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populations
- Fang Chen
- , Daniel O Stram
- & Christopher A Haiman
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Article |
Genome-wide association of breast cancer: composite likelihood with imputed genotypes
- Ioannis Politopoulos
- , Jane Gibson
- & Andrew Collins
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Article |
Risk of breast and prostate cancer is not associated with increased homozygosity in outbred populations
- Victor Enciso-Mora
- , Fay J Hosking
- & Richard S Houlston
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Short Report |
The BRCAPRO 5.0 model is a useful tool in genetic counseling and clinical management of male breast cancer cases
- Ines Zanna
- , Piera Rizzolo
- & Laura Ottini
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Article |
Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression
- Andrzej B Popławski
- , Michał Jankowski
- & Jan P Dumanski