Biotechnology

Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.

Featured

News & Views | 26 January 2023

CLASH enables large-scale parallel knock-in for cell engineering

Nature Biotechnology, 1-2
News & Views | 19 January 2023

sortChIC enables detailed chromatin analysis of rare cell types

Nature Genetics, 1-2
News & Views | 13 January 2023

A scalable technology for measuring cell-type-specific activity of cis-regulatory sequences

Nature Genetics, 1-2

Latest Research and Reviews

Research
28 January 2023 | Open Access

Prediction of heavy metal biosorption mechanism through studying isotherm kinetic equations
- Mostafa G. Fadl
Scientific Reports 13, 1576
Research
28 January 2023 | Open Access

Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands

Injectable biomimetic hydrogels hold significant promise for tissue engineering applications. Here, the authors present a hybrid myoglobin:peptide hydrogel to overcome a critical oxygen shortage following neural stem cell transplantation, thus increasing cell survival and integration.
- Y. Wang
- , E. R. Zoneff
- & D. R. Nisbet
Nature Communications 14, 457
Research
28 January 2023 | Open Access

A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens

Antigen display on outer membrane vesicles (OMVs) can be difficult to control and highly variable. Here, the authors describe a universal approach called AvidVax for linking biotinylated antigens to the exterior of OMVs and enabling rapid vaccine assembly.
- Kevin B. Weyant
- , Ayomide Oloyede
- & Matthew P. DeLisa
Nature Communications 14, 464
Research
27 January 2023 | Open Access

Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production
- Yesenia Latorre
- , Mauro Torres
- & Claudia Altamirano
Scientific Reports 13, 1482
Research
27 January 2023 | Open Access

Beneficial metabolic transformations and prebiotic potential of hemp bran and its alcalase hydrolysate, after colonic fermentation in a gut model
- Lorenzo Nissen
- , Flavia Casciano
- & Andrea Gianotti
Scientific Reports 13, 1552
Research
27 January 2023 | Open Access

Human profiling from STR and SNP analysis of tropical bed bug, Cimex hemipterus, for forensic science
- Li Lim
- & Abdul Hafiz Ab Majid
Scientific Reports 13, 1506

All Research & Reviews

News and Comment

News & Views | 26 January 2023

CLASH enables large-scale parallel knock-in for cell engineering

CLASH is a CRISPR-based platform that enables the parallel knock-in via homology-directed repair of a large pool of transgene variants encoded in adeno-associated virus vectors. CLASH can be applied to the systematic and unbiased selection of favorable features in T cells and, in principle, other cell types.

Nature Biotechnology, 1-2
Comments & Opinion | 25 January 2023

CRISPR-based assays for low-resource settings

CRISPR-based assays can be adopted as ultrasensitive molecular diagnostics in resource-limited settings, but point-of-care applications must address additional requirements. Here, we discuss the major obstacles for developing these assays and offer insights into how to surmount them.
- Zhen Huang
- , Christopher J. Lyon
- & Tony Y. Hu
Nature Reviews Bioengineering, 1-2
Comments & Opinion | 24 January 2023

Biomaterials for intranasal and inhaled vaccine delivery

Delivery of vaccines by nasal sprays may enable more robust, protective mucosal immune responses against infectious diseases, such as COVID-19, compared with intramuscular injection. In this Comment, we highlight how biomaterials can be designed to allow intranasal and inhaled vaccination.
- Devorah Cahn
- , Mayowa Amosu
- & Gregg A. Duncan
Nature Reviews Bioengineering, 1-2
Research Highlights | 23 January 2023

Leveraging the power of crowds
- Fernando Chirigati
Nature Computational Science 3, 2
Research Highlights | 23 January 2023

Cas9–gRNA delivery via grafting
- Jun Lyu
Nature Plants, 1
Comments & Opinion | 23 January 2023

Wearable breath analysis

Biomarkers in breath can be related to certain diseases, which makes breath-based analysis a powerful diagnostic tool. Here we highlight milestones and remaining challenges for the broad clinical implementation of wearables for breath analysis.
- H. Ceren Ates
- & Can Dincer
Nature Reviews Bioengineering, 1-3

All News & Comment

Biotechnology

Featured

CLASH enables large-scale parallel knock-in for cell engineering

sortChIC enables detailed chromatin analysis of rare cell types

A scalable technology for measuring cell-type-specific activity of cis-regulatory sequences

Latest Research and Reviews

Prediction of heavy metal biosorption mechanism through studying isotherm kinetic equations

Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands

A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens

Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production

Beneficial metabolic transformations and prebiotic potential of hemp bran and its alcalase hydrolysate, after colonic fermentation in a gut model

Human profiling from STR and SNP analysis of tropical bed bug, Cimex hemipterus, for forensic science

News and Comment

CLASH enables large-scale parallel knock-in for cell engineering

CRISPR-based assays for low-resource settings

Biomaterials for intranasal and inhaled vaccine delivery

Leveraging the power of crowds

Cas9–gRNA delivery via grafting

Wearable breath analysis

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