Biological models

Biological models are experimental systems that recreate aspects of human tissue function or disease. For example, certain tumour cell lines may serve as cancer models, and transgenic mice that express human beta-amyloid protein may serve as animal models of Alzheimer’s disease.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Aitken et al. have used mutagen-induced liver tumours to trace individual strands of the DNA double helix to which damage occurred and correlate this with mutational patterns to inform upon tumour evolution.

    • Anna Dart
  • News and Views |

    Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now shown to engage YAP/TAZ to rewire cell mechanics and initiate tumorigenic reprogramming.

    • Sayan Chakraborty
    •  & Wanjin Hong
    Nature Materials 19, 707-709
  • News and Views |

    KEAP1 is a tumor suppressor encoded by a gene commonly mutated in lung cancer. A systematic search for Keap1-mutant cancer vulnerabilities now reveals that Slc33a1 is a context-specific essential gene that represents a promising new anti-cancer target.

    • Luke A. Gilbert
    Nature Cancer 1, 575-576